【Abstract】 Objective To investigate the feasibility,.safety and the therapeutic efficacy of laparoscopic splenectomy in nontraumatic splenomegaly. Methods The clinical data were selected from January 2009 to June 2013 in our hospital. Forty patients underwent laparoscopic or open splenectomy for nontraumatic splenomegaly..Among 40 cases,.22 cases received laparoscopic splenectomy as laparoscope group.(LS),.the other 18 cases received traditional open splenectomy as the operation group.(OS)..The perioperative indexes of the two groups were observed and analyzed. Results In the LS group,.2 cases (9.1%) were converted to open splenectomy due to bleeding during operation,.6 cases received simultaneously laparoscopic porta-azygous devascularization, 4 cases received simultaneously laparoscopic cholecystectomy. While in the OS group, 7 cases underwent simultaneously porta-azygous devascularization,.3 cases underwent simultaneously cholecystectomy..The spleen weight, volume and length were not statistically significant.(P>0.05) between two groups..Although the average operative time of LS was longer than that of OS, but the intraoperative blood loss and blood transfusion of LS were less than that of OS,.the differences were statistically significant(P<0.05)..The mean postoperative hospital stay of LS was 7.6±1.8.(d),.and was less than that of OS 10.1±2.1.(d),.the difference was statistically significant (P<0.01)..The postoperative complication rate of LS was lower than that of OS (18.2% vs 38.9%,.P<0.05)..There were no dead case in two groups. Conclusion Laparoscopic splenectomy for non-traumatic splenomegaly is feasible,.safe.