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Table of Content

    20 October 2022, Volume 22 Issue 05
    Original Articles and Clinical Research
    Observation of the safety and long-term efficacy of laparoscopic liver resection for the treatment of hepatocellular carcinoma
    LUO Fa, YAN Qing, CHEN Huan-wei
    2022, 22(05):  441-445.  DOI: 10.3969/j.issn.1009-976X.2022.05.002
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    Objective To Investigate the safety and long-term efficacy of laparoscopic liver resection for patients with hepatocellular carcinoma. Methods The clinical data of 197 hepatocellular carcinoma patients with treated in Foshan First People′s Hospital from January 2014 to December 2019 were retrospectively analyzed. The data were analyzed for their perioperative indexes such as operative time, intermediate open rate, intraoperative blood loss, intraoperative blood transfusion and postoperative complications, mean postoperative hospital stay, tumor recurrence rate, tumor-free survival rate, and overall survival at 1, 3 and 5 years after surgery. Results There were no deaths during the perioperative period. Intraoperative blood loss was 263. 59±; 252. 9 mL, the operation time was 320. 5±; 119. 56 min. There was no perioperative death, no postoperative liver failure, no postoperative wound infection; 9 cases of abdominal effusion, 9 cases of pleural effusion after operation. There were 3 cases of bile leakage, 4 cases of postoperative bleeding, and 2 cases of postoperative pneumonia. The total complication rate was 13. 7%. The postoperative hospital stay was 8.9±; 3.63 days. Followed up until June 1 2021, a total of 67 patients had tumor recurrence. The median tumor-free survival time was 78 months, and the recurrence rate was 34%. The tumor-free survival at 1, 3, and 5 years after surgery was 84. 2%, 65. 2%, and 59. 4%. The overall survival period of 1, 3, and 5 years after operation was 96. 3%, 86. 8%, and 83. 6%. Conclusion Laparoscopic hepatectomy for hepatocellular carcinoma is safe and feasible, its long-term outcomes do not differ significantly from those of open hepatectomy.
    circUTRN24 mediates liver fibrosis in biliary atresia through hepatic stellate cell autophagy
    LIU Dong, GAO Jia-hui, ZHANG Xi-yun, MEI Qian-qian, WU Zhou-guang
    2022, 22(05):  446-450.  DOI: 10.3969/j.issn.1009-976X.2022.05.003
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    Objective To explore the relationship between circUTRN24 and autophagy in biliary atresia, and whether circUTRN24 participates in the process of liver fibrosis in biliary atresia through autophagy. Methods The expressions of circUTRN24 and autophagy related proteins in liver tissues of BA group and CC group were detected by RT-qPCR and Western blot, and the correlation was analyzed. At the cellular level, human hepatic stellate cell line LX-2 overexpressed circUTRN24 by lentivirus transfection. Western blot was used to detect the expression of autophagy related proteins Beclin-1, LC3 and HSC activation related factors α-SMA and COL-Ⅰbefore and after transfection. Results The expressions of circUTRN24 and autophagy related proteins Beclin-1 in the liver tissue of children with biliary atresia were significantly higher than those in the control group, and there was a positive correlation between them. Overexpression of circUTRN24 in LX-2 cells significantly increased autophagy related proteins(Beclin-1 and LC3-Ⅱ) and HSC activation related factors(α-SMA and COL-Ⅰ). Conclusion circUTRN24 may promote the progression of hepatic fibrosis in biliary atresia by regulating the autophagy of hepatic stellate cells.
    Cost-effectiveness and Qol of PEGrhGCSF prophylaxis for breast cancer patients receiving adjuvant chemotherapy
    CHEN Wan-na, LIANG Xiao-li, ZHANG Zhan-qiang, XU He-yang, LIN Bo, ZHANG Zhao-xi, YU Ju, ZHENG Liang, HUANG Jin-yao, ZHANG Jing, LU Yi-lin, HUANG Jia-yong, LI Rui-xia, LI Jie, LV Wei-ming
    2022, 22(05):  451-457.  DOI: 10.3969/j.issn.1009-976X.2022.05.004
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    Objective To analyze the cost-effectiveness of PEGrhGCSF prophylaxis for breast cancer patients receiving adjuvant chemotherapy and its effect on quality of life (Qol). Methods This is a prospective cohort study. The breast cancer patients receiving adjuvant chemotherapy in our department were included and grouped by whether PEGrhGCSF was used or not. Complete blood count was monitored during chemotherapy cycle. Medical related bills were recorded and Qol was evaluated using FACT-B questionnaire. The rates of severe neutropenia and delay of next chemotherapy, medical related cost and Qol were compared between groups. Incremental cost benefit ratio (ICER) was calculated. Results Totally 256 patients were included in analysis. Compared with control group, PEG-rhG-CSF group had lower rates of severe neutropenia (9.3% vs. 20.6%, P = 0.030) and delay of next chemotherapy (5.2% vs. 15.9%, P=0.010), and better Qol in physical well-being scale. The total cost was higher in PEG-rhG-CSF group, but the difference was not statistically significant (2102.95 CNY vs. 1816.85 CNY, P=0.31). The ICERs for severe neutropenia and delay of next chemotherapy were 25.32 CNY/1% and 24.45 CNY/1%, respectively. Conclusion PEGrhGCSF prophylaxis for breast cancer patients receiving adjuvant chemotherapy was cost-effective and associated with better Qol.
    Effect of pelvic floor peritoneal reconstruction on minimally invasive low anterior resection in patients with rectal cancer
    SUN Zhen-zhi, HUANG Jian-feng, WANG Tao, JIN Ji-tao, NIE Yong, YU Gui-qiao
    2022, 22(05):  458-462.  DOI: 10.3969/j.issn.1009-976X.2022.05.005
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    Objective To explorethe effect of pelvic floor peritoneal reconstruction on the effect and complications of minimally invasive low anterior resection in patients with rectal cancer. Methods 128 patients with rectal cancer who received minimally invasive low anterior resection in our hospital from January 2017 to January 2021 were selected as the research subjects, and the subjects were divided into two groups according to the surgical method, and 64 cases underwent pelvic floor peritoneal reconstruction surgery 64 patients without pelvic floor peritoneal reconstruction were included in the control group and were followed up for 6 months. The surgical results and perioperative indicators of the two groups were compared and analyzed. Results The operation time of the observation group was significantly higher than that of the control group (P<; 0.05). The postoperative hospital stay in the observation group was significantly lower than that in the control group (P<; 0.05). The incidence of anastomotic leakage, grade C anastomotic leakage, abdominal infection, pelvic infection and intestinal obstruction in the observation group was lower than that in the control group, and the total incidence of complications in the observation group was significantly lower than that in the control group (P<; 0.05). The second operation rate in the observation group was significantly lower than that in the control group (P<; 0.05). There was no significant difference in serum C-reactive protein and procalcitonin levels between the two groups at 1, 3, and 5 days after operation (P>; 0.05). The original level was lower than 1 day after operation (P<; 0.025). The stool function scores of the observation group after operation, 1 month after operation and 6 months after operation were significantly lower than those in the control group after operation, 1 month after operation and 6 months after operation (P<; 0.05). Conclusion Pelvic floor peritoneal reconstruction can greatly reduce the risk of grade Ⅲ~Ⅳ complications in patients with rectal cancer who undergo minimally invasive low resection, and also reduce the incidence of secondary surgery. Prognosis is facilitative.
    Pelvic autonomic nerve preservation with real-time monitoring during laparoscopic total mesorectal excision for retal cancer
    TAN Ming-hua, DU Guo-neng, LIAO Jian-nan, XIE Hong, OU Xiao-wei
    2022, 22(05):  463-465.  DOI: 10.3969/j.issn.1009-976X.2022.05.006
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    Objective To study pelvic autonomic nerve preservation using real-time minitoring during laparoscopic total mesorectal excison for rectal cancer. Methods We prospectively investegated 11 cases of rectal cancer patients undergoing laparoscopic TME during January 2018 and December 2020. PANP procedure was done using real-time monitoring. The urinary and anorectal function and the correlation between the electromyography and postoperative function were analysed. Results All patients were succsessfully perfomed PANP with real-time monitoring, and all get positive results. The postoperative urinary and anorectal functions of all patients were complete. The correlation between the electromyography and postoperative function was very good(r=1.0). Conclusion Pelvic autonomic nerve preservation using real-time minitoring during laparoscopic total mesorectal excison for rectal cancer is safe and effective and the positive electromyography indicates a complete urinary and anoretal function.
    Role of PARP1 expression in predicting survival of colorectal cancer
    YE Zhen, LIN Ying
    2022, 22(05):  466-474.  DOI: 10.3969/j.issn.1009-976X.2022.05.007
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    Objective To investigate the relationship between the expression of PARP1 and the prognosis of colorectal cancer. Methods the RNA SEQ data of PARP1 gene were downloaded from the Gene Expression Omnibus (GEO) and the Cancer Gene Atlas (TCGA) database. The scatter plot was drawn by R software to analyze the expression level of PARP1 in colorectal cancer and adjacent tissues. The data was divided according to the expression level of PARP1 as high and low expression groups to analyze for survival, subgroup survival and GSEA gene enrichment. The PARP1-related genes were screened and analyzed for GO and KEGG enrichment,and the PARP1 co-expressed genes were identified. Results The mRNA expression of PARP1 in tumor samples was significantly higher than that in non-tumor samples(P<; 0.05)in GSE184093, GSE100179, GSE44076, GSE110225 and TCGA data sets. Taking 6.93 as the threshold, the patients were divided into high and low PARP1 expression groups. The overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and progression free survival (PFS) of patients with high PARP1 expression group were significantly shorter than those with low PARP1 expression group(P<; 0.05). A total of 2629 differentially expressed genes were screened from colorectal cancer and adjacent tissues, of which 765 genes were significantly related to PARP1. GO analysis showed that PARP1-related genes were related to DNA polymerase binding, histone kinase activity, platelet-derived growth factor binding, Cajal body protein localization, telomere protein localization, etc; KEGG analysis showed that PARP1-related genes were related to DNA replication, cell cycle, mismatch repair and other pathways. Conclusion The expression of PARP1 is up-regulated in colorectal cancer and is related to the poor prognosis of colorectal cancer patients.
    Effect of sequential therapy of low temperature and glauber salt to prevent the occurrence of seroma after TAPP
    LIU Xiao-sheng, CHEN Xue-bin, MA Ning, ZHOU Tai-cheng, CHEN Shuang
    2022, 22(05):  475-479.  DOI: 10.3969/j.issn.1009-976X.2022.05.008
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    Objective To investigate the effect of sequential therapy of low temperature and glauber salt in preventing seroma after laparoscopic transperitoneal preperitoneal hernia repair (TAPP). Methods Clinical data of 120 TAPP patients admitted to the General Surgery Department of Wan′an County People′s Hospital and Department of Gastrointestinal Surgery and Hernia Center of the Sixth Affiliated Hospital of Sun Yat-sen University from March 2019 to March 2022 were collected and divided into the study group and the control group with 60 patients in each group by using a computer random number table. In the study group, 200 mL 4℃ saline irrigation was applied to the inguinal area, ice packs compress two hour postoperatively in the inguinal area and two day external application of glauber salt after surgery. In the control group, conventional TAPP postoperative treatment was performed. The main outcome indicators were the incidence of postoperative seroma in two groups, while the secondary outcome indicators included operation time, out-of-bed activity time, length of stay, hospitalization cost, incision pain, VAS score, incidence of malignant vomiting, urinary retention and intestinal obstruction, and long-term follow-up indicators included chronic pain, mesh infection and hernia recurrence. Results The incidence of seroma in study group and control group was 1.7% (1/60) and 16.7% (10/60), respectively, and the difference was statistically significant (P<; 0.05), 1 in the study group belonged to type ⅰ. In the control group, 6 cases were type ⅰ, 2 cases were type ⅱ and 2 cases were type ⅳ. Type ⅳ seroma was gradually relieved after puncture and aspiration guided by B-ultrasound, while type ⅰ and ⅱ seroma were improved after glauber salt external application. The incidence of postoperative incision pain, nausea and vomiting and urinary retention in the study group were 5.0%, 3.3% and 3.3%, respectively, lower than 16.7%, 13.3% and 15.0% in the control group, and the difference was statistically significant (P<; 0.05). VAS score (3.1±; 0.6) points, out-of-bed activity time (8.5±; 2.3) h, and length of stay (3.5±; 0.6) d in the study group were all lower than those in the control group (4.8±; 0.8) points, (13.1±; 1.7) h, and (4.5±; 1.0) d, all of which were statistically significant (P<; 0.05). There were no statistically significant differences between the two groups in terms of operation time, chronic pain in the inguinal region, mesh infection, intestinal obstruction, hospital expenses, and hernia recurrence. Conclusion The sequential therapy of low temperature and glauber salt can effectively prevent the occurrence of seroma after TAPP, with fewer complications, significantly reduce the postoperative pain of patients,promote rapid recovery, and do not increase the economic burden of patients, which is worthy of clinical application and promotion.
    lncRNA-DINO targets miR-141 to regulate the Keap1-Nrf2 pathway to promote non-small cells study on the mechanism of chemoresistance of lung cancer cells
    XIA Yao, XU Lei, TANG Zhi-xian, XIE Chun-fa, ZHU Shen-yu
    2022, 22(05):  480-485.  DOI: 10.3969/j.issn.1009-976X.2022.05.009
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    Objective To study the mechanism of lncRNA-DINO in chemoresistance of non-small cell lung cancer (NSCLC). Methods compare drug-resistant and sensitive NSCLC clinical specimens, detect the expression of DINO, miR-141, Keap1 and Nrf2 by RT-PCR and Western experiment, and explore the relationship between the expression of DINO and miR-141 and chemotherapy resistance. Secondly, A549 cell line and A549 / DDP cell line were cultured, and total RNA was extracted by Trizol (Invitrogen company), The expression difference of lncrna between the two groups of cell lines was detected by lncrna chip. Through the prediction and calculation of online software (rnahybrid), the possibility of DINO binding with miR-141 was evaluated. Finally, A549 cell line and A549/DDP cell line were cultured. Total RNA was extracted by Trizol (Invitrogen company). The DINO, miR-141, Keap1, Nrf2, HO-1 and NQO1 between the two groups were verified by RT-PCR. Results the expression of DINO in drug-resistant A549/DDP cell lines was significantly lower than that in sensitive A549 cells (P<; 0.05), and DINO played a role by binding to miR-141. RT-PCR showed that compared with A549 cells, the expression of Keap1 gene in a549-mir-141 cells overexpressing miR-141 decreased significantly (P<; 0.05), while the expression of PTEN and MSH2 did not change significantly. Compared with A549 cells, the expression of Keap1 gene was down-regulated in a549-mir-141 cells, while the expression of Nrf2 gene and its downstream HO-1 and NQO1 genes were significantly up-regulated (P<; 0.05). Conclusion In non-small cell lung cancer, lncRNA-DINO can target and bind miR-141, and then regulate keap1-nrf2 pathway, resulting in chemoresistance.
    A clinical case-control study of percutaneous sacroiliac screws and percutaneous tension band plate in the treatment of unstable posterior pelvic ring fracture or dislocation
    GUO Yue-yue, ZHENG Chao-shun, HE Xu-hui, LIN Yi-hui, CHEN Bin-yong, LIN Chu-chun, LIN Ben-dan
    2022, 22(05):  486-491.  DOI: 10.3969/j.issn.1009-976X.2022.05.010
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    Objective The aim of this study is to compare the clinical effects between percutaneous sacroiliac screws and percutaneous tension band plate in the treatment of unstable posterior pelvic ring fracture or dislocation. Methods From June,2019 to May 2021, forty patients with unstable posterior pelvic ring fracture or dislocation were enrolled in this study and randomly divided into two groups. Both the percutaneous sacroiliac screws and percutaneous tension band plate has twenty patients and the base data, perioperative clinical data and clinical effects were compared. Results There was no significant statistical difference between the two groups with follow-up time, sex, age, injury cause, type of fracture or dislocation and ISS scores(P>; 0.05). The waiting time before surgery, surgery time, length of incision, intraoperative blood loss were better in the percutaneous sacroiliac screws group while the radiation times were larger(P<; 0.05). The Majeed scores and Matta scores had no stastistical significance between two groups (P>; 0.05). For complication, percutaneous sacroiliac screws groups has two cases of nerve injury and percutaneous tension plate group has two cases of incision infection. Conclusion Percutaneous sacroiliac screws can reduce damage to soft tissues and thus can be a more effective method in the treatment of unstable posterior pelvic ring fracture or dislocation.
    Effect of tracheal passage training on postoperative rehabilitation of anterior cervical decompression and bone graft fusion and internal fixation
    QIN Zhi-rong, CHEN Feng-lian, YUAN Xiang-wei
    2022, 22(05):  492-496.  DOI: 10.3969/j.issn.1009-976X.2022.05.011
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    Objective To investigate the effect of preoperative tracheal nudge training on postoperative complications and postoperative rehabilitation in patients undergoing anterior cervical decompression graft fusion internal fixation. Methods The clinical data of 205 patients who underwent anterior cervical decompression and bone grafting fusion and internal fixation from January 2017 to July 2021 in Jiangmen Central Hospital were retrospectively analyzed. Among them, 122 patients underwent single-segment anterior cervical decompression-implant fusion and internal fixation, and 83 patients underwent double-segment anterior cervical decompression-implant fusion and internal fixation. Sixty-two of the single-segment patients were in the preoperative tracheal nudge training group, and 60 were in the control group. Forty-five of the bipartite patients were in the tracheal nudge training group, and 38 were in the control group. The indicators observed and analyzed included postoperative choking on drinking water, hoarseness, duration of throat pain, degree of throat pain, postoperative hoarseness and postoperative dysphagia. Results All 205 patients completed the surgery successfully, and no patients died. In patients with single-segment anterior cervical decompression graft fusion internal fixation, there were no statistically significant differences between the tracheal nudge training group and the control group in terms of postoperative water choking, postoperative hoarseness, and postoperative dysphagia (P>; 0.05), but the duration of postoperative throat pain was shorter and the degree of postoperative throat pain was less severe in the tracheal nudge training group than in the control group (P<; 0.05). In patients undergoing anterior decompression graft fusion internal fixation of the cervical spine in both segments, fewer patients in the tracheal nudge training group experienced postoperative choking on drinking water, hoarseness, and dysphagia than in the control group (P<; 0.05), and postoperative throat pain was shorter and less severe (P<; 0.05). Conclusion Preoperative tracheal nudge training in patients undergoing anterior cervical decompression-implant fusion internal fixation is beneficial to patients′ rapid postoperative recovery and enhances their postoperative comfort, especially for patients undergoing anterior cervical decompression-implant fusion internal fixation in both segments.
    The learning curve of goal-oriented retroperitoneoscopic adrenal lesion resection
    JI Zhen-shuai, XIE Cheng, ZHANG Peng-cheng, CAI Cheng-kuan, ZHI Yun-lai, ZHANG Zhi-gang, SUN Fang-hu
    2022, 22(05):  497-502.  DOI: 10.3969/j.issn.1009-976X.2022.05.012
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    Objective To evaluate the learning curve of goal-oriented retroperitoneoscopic adrenal lesion resection measured by operative length and intraoperative blood loss. Methods The clinical data of 60 patients underwent Goal-oriented retroperitoneoscopic adrenal lesion resection completed by the same group of surgeons from January 2019 to January 2021 were retrospectively analyzed. All the cases were divided into group A(case 1 to 15), group B (case 16 to 30), group C(case 31 to 45), group D (case 46 to 60). Operative length, intraoperative blood loss, incision length and postoperative hospital stay were analyzed and differences between groups were compared. Results By the statistical analysis, the operative length and intraoperative blood loss was decreasing with the increase of cases. By multiple comparison,differences of the operative length and intraoperative blood loss between group A and group B, C, D were significant (P<; 0.05). Differences of the operative length and intraoperative blood loss between group B and group C, D were significant (P<; 0.05). There was no significant difference differences of the operative length and intraoperative blood loss between group C and group D (P>; 0.05). There were no statistical significant difference differences of incision length and postoperative hospital stay between the four groups (P>; 0.05). Conclusion For the urologist with rich retroperitoneoscopic adrenal lesion resection experience, the learning curve of the Goal-oriented retroperitoneoscopic adrenal lesion resection is the accumulation 30 cases of experience.
    Analysis of the expression and significance of GPX4 in prostate cancer based on database mining
    LI Jin, LI Ling-feng, LAI Yi-ming
    2022, 22(05):  503-508.  DOI: 10.3969/j.issn.1009-976X.2022.05.013
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    Objective To analyze the expression level of phosphatidyl glutathione peroxidase 4 in prostate cancer and its significance with clinical prognosis by database mining. Methods Ualcan and GEPIA2 databases were used to analyze the expression level of GPX4 in prostate cancer. The linked Omics database was used to investigate the relationship between GPX4 and the clinicopathological stage, lymph node metastasis, Gleason score and survival prognosis of prostate cancer. The methylation level of the promoter region of GPX4 gene was assessed through the MethHC 2.0 methylation database to probe the effect of methylation on the promoter region of GPX4. The downstream molecules and related network diagrams of GPX4 gene regulation were constructed using the String database. Results Compared with normal prostate tissue, the expression level of GPX4 mRNA in prostate cancer tissue was significantly increased (P=0.000 2). Pan-cancer expression analysis showed that GPX4 was high expression in bladder cancer, kidney cancer, urothelial cancer and other urinary system tumors. The mRNA expression level of GPX4 was correlated with the clinicopathological stage, lymph node metastasis and Gleason score of prostate cancer. Survival analysis showed that GPX4 had no correlation with the overall survival of prostate cancer patients, but patients with high GPX4 had lower recurrence-free survival. The methylation expression level of GPX4 gene DNA promoter region in prostate cancer was significantly higher than that in normal prostate epithelial tissue. The results of protein network analysis suggested that GPX4 may play a role inferroptosis, glutathione metabolism, superoxide dismutase 2, Catalase and other pathways. Conclusion The high expression of GPX4 gene in prostate cancer is an effective biomarker for predicting the occurrence and development of prostate cancer patients.
    The expression and prognostic significance of FDX1 in glioma
    ZHANG Bo-hong, XIE Lin, OUYANG Le-ping, HE Ming-liang
    2022, 22(05):  509-511.  DOI: 10.3969/j.issn.1009-976X.2022.05.014
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    Objective To investigate the expression and clinical significance of FDX1 in malignant glioma. Methods Immunohistochemical method was used to detect the expression of FDX1 in 40 glioma samples and 20 traumatic brain samples. The relationship between the expression of FDX1 and clinicopathological factors was analyzed. Kaplan-Meier methodwas used for survival analysis. Results The expression of FDX1 in glioma samples was significantly higher than that in non-neoplastic brain samples (P<; 0.01). The expression of FDX1 was positively related with pathology classification of glioma (P<; 0.01). Kaplan-Meier curve showed that the overall survival rate of patients in the high expression group of FDX1 was significantly lowerthan that in the low expression group (P<; 0.01). By multivariate Cox analysis, FDX1 and classification were identified as the independent predictive factors. Conclusion FDX1 may play an important role in the occurrence and development of glioma, and may serve as a biomarker of poor prognosis.
    Case Report
    Human endocarditis caused by porcine streptococcus suis type I infection: a case report and literature review
    LI Jing-wen, JIANG Hui-qi, LIU Cong-yong, GAO Min-nan, TANG Fang, YANG Yan-qi
    2022, 22(05):  512-516.  DOI: 10.3969/j.issn.1009-976X.2022.05.015
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    Human infective endocarditis (IE) caused by S. suis I has to our knowledge never been reported. We hereby report a case of restaurant cooker who suffered from infective endocarditis caused by S. suis I, and underwent successful treatment. A literature review was made to systemically summarize the current knowledge about diagnosis and treatment of the disease.
    Intussusception caused by varus of giant Meckel diverticulum in a middle-aged male
    TANG Xiao-bo, LI Xin-yi, HUANG Jin-tuan
    2022, 22(05):  517-519.  DOI: 10.3969/j.issn.1009-976X.2022.05.016
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    The clinical data of intussusception caused by varus of giant Meckel diverticulum treated in our hospital were retrospectively analyzed. The patient was a middle-aged male who was admitted to the hospital due to acute exacerbation of chronic abdominal pain. Before surgery, ileal intussusception was considered. During the operation, the ileocecal intussusception was observed at a location of 60 cm from the lower abdomen, and the insertion was a 13 cm Meckel diverticulum. Adult Meckel diverticulum is rarely seen clinically and can be asymptomatic throughout life. The clinical manifestations are not specific at the onset, and complications such as gastrointestinal bleeding and intestinal obstruction are often treated. Intussusception due to varus of giant Meckel diverticulum in adults is rare.
    Review
    Application status of indocyanine green in hepatobiliary laparoscopic surgery
    CHEN Qiu-kai, DAI Wei
    2022, 22(05):  520-525.  DOI: 10.3969/j.issn.1009-976X.2022.05.017
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    With the development of fluorescence detection technology, the role of indocyanine green (ICG) has evolved from preoperative liver function evaluation to tumor diagnosis, visualization of precancerous lesions and lymphatic vessels, intraoperative tumor detection and precision of guiding surgery. ICG fluorescence guided hepatectomy fundamentally improves the ability of liver anatomy and the quality of surgery, and also improves the safety and accuracy of minimally invasive (laparoscopic and robotic) hepatobiliary surgery. Because ICG fluorescence technology can better display the cancer focus and guide the resection edge away from the tumor boundary, the current hepatobiliary surgery can no longer lack the application of ICG. In view of the fact that the study of ICG related clinical applications has become a hot spot, this article discusses the application status of ICG fluorescence imaging in hepatobiliary surgery.
    Progress of pericapsular nerve block of hip joint
    LU Si-hui, LONG Shang-qian, LIU Xian-bao
    2022, 22(05):  526-530.  DOI: 10.3969/j.issn.1009-976X.2022.05.018
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    Pericapsular Nerve Group (PENG) block of hip joint is a new regional anesthesia method of nerve block. It was first used for anesthesia in hip joint surgery and perioperative analgesia, and has gradually been applied to lower limb amputation, varicose ligation and stripping of great saphenous vein, and resection of medial thigh mass and other lower limb operations. PENG block can block obturator nerve simply and almost perfectly, produce good perioperative analgesia, reduce the demand for opioids and related adverse reactions, and do not affect the muscle strength of lower limbs, which makes many experts at home and abroad pay more and more attention to it in recent years.This paper reviews the advances in clinical research on the anatomical basis of PENG block, the analysis of B-ultrasound-guided anesthesia technology and its effect in lower extremity surgery. This paper reviews the advances in clinical research on the anatomical basis of PENG block, the analysis of B-ultrasound-guided anesthesia technology and its effect in lower extremity surgery.