Objective To evaluate the efficacy of hernioplasty using small intestinal submucosa mesh to repair inguinal hernia in adolescent patients aged from 14 to 18 years. Methods Forty-seven cases of adolescent patients were divided into two groups, the treatment group and the control group. The patients in treatment group were treated with small intestinal submucosa mesh, while the patients in control group underent high ligation of hernia sac. The operation time, the amount of bleeding, the time of hospitalization, postoperative complications and recurrence were observed and analyzed. Results The average operative time in the treatment group(51.6 ± 12.7 min)was higher than that in the control group (38.2 ± 7.5 min)(P<0.05), and the average hospitalization time(3.4 ± 1.1 d)was lower than that in the control group(5.1±1.3 d)(P<0.05). There was no significant difference in the amount of bleeding between the treatment group(14.4±6.5)ml and the control group(13±5.9)ml(P>0.05). There were no significant differences in the incidence of postoperative complications, recurrence rate and postoperative pain score between two groups. Conclusion For adolescent patients with inguinal hernia aged from 14 to 18 years, the use of small intestinal submucosal mesh for tension-free hernia repair is effective, which could shorten the length of hospital stay, and would not increase the incidence of postoperative pain and complications.