【Abstract】〓Objective〓To investigate the value of plasma level of lipoprotein at prognosis of breast tumor. Methods〓Clinical data of 244 patients with breast cancer under therapy in the Sun Yat-sen Memorial Hospital and 99 healthy donors during November 2003 to September 2008. First, the plasma metabolic indexes were compared between the healthy donors and breast cancer patients. Furthermore, Spearman association showed breast cancer patients with high TC or LDL-C had larger tumor size and ER/PR deficiency. Cox regression model was used to analyze the disease free survival (DFS) curve and evaluate the prognostic factors of DFS. Results〓The plasma level of total cholesterol, LDL-C, triglyceride, glucose were higher in breast cancer patients than those in healthy donors, while HDL-C was reverse. The high plasma level of total cholesterol, LDL-C were more inclined to present at Her-2 positive or triple negative breast cancer, than ER/PR positive substyle. There was positive correction between tumor size and TC or LDL-C. Moreover, Cox regression model showed poorer DFS in the group with TC≥5.2 mmol/L or LDL-C>3.08 mmol/L than that with TC<5.2 mmol/L or LDL-C≤3.08 mmol/L (TC 68% vs 77.7%, LDL-C 73.4% vs 86.3%, P<0.05), which revealed that TC or LDL-C was independent prognostic factors of breast cancer progression. Conclusion〓Plasma level of TC or LDL-C was an independent prognostic factor of breast cancer progression.
