Table of Content

20 April 2014, Volume 14 Issue 02

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论文

Long-term aseptic joint loosening and primary osteoporosis

Ding Yue, Fu Guangtao

2014, 14(02):  115-117.  DOI: 10.3969/j.issn.1009-976X.2014.02.001

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Study on CXCL12/CXCR4 promoting prostate cancer stem cells docetaxel resistance via phosphorylating Akt

Liu Cheng, Bi Liangkuan, Xu Kewei

2014, 14(02):  118-121.  DOI: 10.3969/j.issn.1009-976X.2014.02.002

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【Abstract】Objective To explore the expression of chemokine (C-X-C motif) receptor 4 (CXCR4) in prostate cancer stem cells (PCSCs), and the role of CXCR4 in PCSCs docetaxel resistance. Methods FACS was employed to measure the expression of CXCR4 on PCSCs and non-PCSCs surfaces; MTS was conducted to evaluate the cell viability under different concentration of docetaxel, and IC50 was calculated according to the dose-effect curves; CXCL12 or antibody against CXCR4 were used before docetaxel was added into the medium, and cell viability was measured by MTS; Western blotting was conducted to test the activation of signaling pathways. Results PCSCs cells contained 74.24% CXCR4 positive cells, while only 20.39% cells were CXCR4 positive in non-PCSCs (P<0.05); IC50 of docetaxelwas 7.5 μM in PCSCs, and 0.6 μM in non-PCSCs; 72 hours after docetaxel treatment, cell viability was 92.15±3.44% in CXCL12 group, 68.46±4.16% in anti-CXCR4 group, and 70.24±3.52% in negative control group; CXCL12 could significantly increase Akt phosphorylation in PCSCs. Conclusion CXCL12 activate the Akt signaling pathway via CXCR4 on PCSCs, inducing the docetaxel resistance of PCSCs, which may be one of the important mechanisms underlying the desensitization of docetaxel in PCSCs.

The impact of MALAT1 on cellular function of bladder cancer cell line UMUC3 and its downstream target genes

Wang Pei, Jiang Chun, He Wang, Ling Tianxin, Huang Jian

2014, 14(02):  122-126.  DOI: 10.3969/j.issn.1009-976X.2014.02.003

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【Abstract】〓Objective〓To investigatethe effect of MALAT1 on regulationof proliferation, migration, invasion, clone formation, and other functions in UMUC3 cell lines of bladder cancer, and to explore the molecular mechanism of MALAT1 in bladder cancer. Methods〓Thesmall interfering RNA (siRNA) was designed and synthesized and then transfected into the UMUC3 cells. The transfection efficiency was detected with RT-QPCR assay. MTS assay, transwell migration and matrigel invasion assay, colony formation assay and 5-ethinyl-2′-deoxyuridine (EDU) assay were performed to evaluate the proliferation, migration, invasion, clone formation and cell cycle respectively. To explore the potential pathways of MALAT1, we performed gene chip assay. Results〓After down regulation the expression of MALAT1, the proliferation, invasion, migration and colony-forming ability of UMUC3 bladder cancer cells were impaired. Gene chip found that cancer pathways related gene changed obviously after knockdown of MALAT1 in UMUC3 cells. Conclusion〓MALAT1 promoted the proliferation, invasion, migration, cell cycle and clone formation ability in UMUC3 cell lines of bladder cancer through modulating the cancer pathways related gene activation and deactivation.

Anatomic study on surgical procedure of posterior approach laparoscopic pancreaticoduode=nectomy

Zhou Rui, Min Jun, Lin Haoming, Li Guolin, He Hai, Yang Xiaofei, Ding Zihai,

2014, 14(02):  127-131.  DOI: 10.3969/j.issn.1009-976X.2014.02.004

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【Abstract】〓Objective〓To invesgate regional anatomy features of related vessels and surgical planes in posterior approach laparoscopic pancreaticoduodenectomy (paLPD). Methods〓In order to distinguish related vessels in paLPD accurately, we explored anatomy symbols, exposure methods and search for safe surgical planes under laparoscopic visions by means of analysis from 25 patients surgery videos and observing anatomy features of 15 adult specimens. Results〓Four regions are identified as important surgical planes in paLPD,including the avascular region between posterior pancreas duodenum and prerenal fascia,the avascular region between posterior pancreatic neck and superior mesenteric vein, the region between pancreatic uncinate process and mesenteric vessels, and the celiac trunk and hepatoduodenal ligament regions,and they cover all related vessels in paLPD. Operating along accurate surgical planes,we can not only reduce vessels injury risks,but also improve surgery efficiency and follow the “en bloc” principle better. Conclusion〓paPLD is a safety and feasible way in LPD,and we can improve surgery safety and efficiency by mastering the features of related vessels under laparoscopic visions and operating along accurate surgical planes.

The expression of CGRP in nerve fiber and periosteum of diabetic foot and its effects on osteoclasts differentiation and MMPs expression

Liu Wenzhou, Chen Binghao, Aditya Anand, Chen Xiangyu, Yang Tao, Song Weidong

2014, 14(02):  132-135.  DOI: 10.3969/j.issn.1009-976X.2014.02.005

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【Abstract】〓Objective〓To detect the expression of calcitonin gene-related peptide (CGRP) in nerve fiber and periosteum of diabetic foot and its effects on osteoclasts differentiation and Metal Matrix Proteinases (MMPs) expression. Methods〓Immunohistochemical staining was utilized to detect the expression of CGRP in nerve fibers and periosteum of diabetic foot patients and traumatic amputees (as controls). RAW 264.7 cells were treated with CGRP to study its effects on osteoclasts differentiation and MMPs expression.TRAP staining was used to determine osteoclasts and western-blot was utilized to detect the expression of MMP-2,MMP-3 and MMP-9. Results〓The expression of CGRP in nerve fibers and periosteum was deceased in Diabetic foot patients.CGRP inhibited the differentiation of osteoclasts and decreases the expression of MMP-3 and MMP-9. Conclusion〓The decreased CGRP in diabetic foot can result to MMPs over-expression of osteoclasts due to activation,leading to bone destruction and refractory foot ulceration and may play an important role in the pathogenesis of diabetic foot.

Mechanism of morphine on proliferation of pheochromocytoma cells

Chen Weiqiang, Liu Funing, Liu Ling, He Huiyan, Cao Minghui

2014, 14(02):  136-139.  DOI: 10.3969/j.issn.1009-976X.2014.02.006

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【Abstract】〓Objective〓To investigate the effects of morphine on roliferation of pheochromocytoma cell and its mechanism. Methods〓PC12 cell cultures were exposed to 10,20,30 μmol/L morphine. The inhibition of the cell proliferation was determined by MTT assay. The level of p38MAPK was detected by immunoblotting. Results〓The proliferation of PC12 cells were inhibited after morphine exposure for 48 h.Immunoblotting showed that morphine increased the phosphorylation of p38MAPK was increased in stimulation of monphine. SB203580, the inhibitor of p38MAPK, reduced inhibition the proliferation of PC12 cells by morphine. Conclusion〓These results suggest that morphine can significantly inhibits the proliferation of PC12 cells by an increase in p38MAPK phosphorylation.

Surgical experience of 22 cases with liver tumor in children

Zou Yan,He Xiaobing,Pan Jing,Yang Jiliang, Yang Tianyou, Li Guisheng

2014, 14(02):  140-142.  DOI: 10.3969/j.issn.1009-976X.2014.02.007

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【Absract】〓Objective〓To investigate clinical characteristics of liver tumor in children. Methods〓A retrospective study was conducted in 22 cases of children with liver tumor between Jan 2011 to Jun 2013. AFP and CT/CTA scan were detected before operation. Twenty two cases were diagnosed by pathological examination...Among them,17 patients underwent surgical operation,..7 cases of them using CUSA and (or) Ligasure energy platform. Results〓CT scan showed 7 tumors in left lobe, 12 tumors in right lobe,..and 3 tumor between right and feft lobe...Pathological exam showed 14 hepatoblastoma,3 focal nodular hyperplasia, 2 infantilism angioendothelioma, 1 fibrous hamartomas,1 embryonic undifferentiated sarcoma,1 simple cyst...Eight cases underwent liver resection with CUSA and Ligasure,..the average of blood loss was 121 mL...9 cases underwent liver resection and the average blood loss was 248 mL. There were statistically significant differences between two groups, P<0.05. The hepatic porta were blocked in 7 cases and the average blood loss was 170 mL. Non-blocking was in 10 cases,..the average blood loss was 198.64 mL and there was no significant difference between the two groups...Seven cases with benign tumors were disease-free survival after operation. One case with embryonic undifferentiated sarcoma died six months after operation. In the 14 cases with hepatoblastoma, 9 cases underwent liver resection and these patients survived to now. And in 5 cases only received puncture biopsy of liver,4 cases died and 1 case survived. Conclusion〓Using precise liver resection to treat pediatric liver lesions, both benign and malignant,it is safe and effective. But in the hilum invaded or more than 3 lobes of the liver tumor,further improving therapeutic measures are necessary.

Postoperative carbohydrate antigen 724 (CA724) and CEA expressions as prognostic factors in patients with colorectal cancer

Li Guowen, Zeng Shanqi, Wang Chenxing, Li Lishan, Ye Hua, Yang Ping

2014, 14(02):  143-146.  DOI: 10.3969/j.issn.1009-976X.2014.02.008

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【Abstract】〓Objective〓To detect the serum carbohydrate antigen 724 (CA724) and embryonic antigen (CEA) expression levels in colorectal cancer patients and observe the correlation between both of them. Methods〓Thirty-eight colorectal cancer patients as observer group; and 38 patients without recurrence or metastasis of cancer as control group. After taking the fasting blood, the serum levels of CA724 and CEA were detected using electrochemiluminescence method. Besides, the correlation of CA724 with CEA was tested using Pearson correlation coefficient. Results〓The serum levels of CA724 and CEA were higher in colorectal cancer patients than those in the control group. And the differences were statistically significant (P<0.01). In 76 patients, the serum levels of CA724 and CEA were significantly correlated, (correlation coefficient r=0.622, P<0.01). Conclusion〓CA724 and CEA are significantly increased in the serum of advanced colorectal cancer patients..And the serum level of CA724 is significantly correlated with the serum level of CEA in colorectal cancer patients..CA724 as an follow-up indicator of colorectal cancer after operation of is worthy of further study.

Laparoscopic microwave coagulation therapy combined with liver resection for hepatocellular carcinoma in severe cirrhotic patients

Zhang Hongwei,.Luo Xuan, Cao Jun, Li Wenda, Zhang Kelin, Chen Yajin

2014, 14(02):  147-149.  DOI: 10.3969/j.issn.1009-976X.2014.02.009

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【Abstract】〓Objective〓To investigate the safety and feasibility of laparoscopic microwave coagulation therapy combined with liver resection for hepatocellular carcinoma in cirrhotic patients. Methods〓The medical records have been reviewed retrospectively in 20 patients who underwent laparoscopic microwave coagulation therapy combined with hepatectomy. Results〓Surgical procedures were completed successfully in all cases without conversion..The mean operation time was 112.80 min and the mean blood loss in operation was 116.50 mL..The mean hospital stay was 10.7 days..The complications after operation included pneumonia in one case and mild transient coagulopathy in 2 cases. There were no postoperative bile leaks,.abdominal massive bleeding,.hepatic failure,.and death. Conclusions〓Laparoscopic microwave coagulation therapy combined with liver resection for hepatocellular carcinoma in cirrhotic patients is safe and feasible in selected patients.

Effect of alpha-fetoprotein response for treatment of advanced hepatocellular carcinoma patients with sorafenib

Li Liusheng, Huang Pinbo, He Chuanchao, Xiao Zhiyu

2014, 14(02):  150-152.  DOI: 10.3969/j.issn.1009-976X.2014.02.010

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【Abstract】〓Objective〓To investigate the usefulness of AFP response in sorafenib therapy patients with advanced hepatocellular carcinoma. Methods〓Forty-five patients who received sorafenib therapy with unresectable or metastatic HCC were included in this study from Aug 2008 to Aug 2012. Patients were set up into two groups according to the response of AFP. The relationship between different clinical variable factors and curative effects of sorafenib was analyzed by using Cox proportion hazard regression analysis and the side effects were also estimated. Results〓Of these cases, Fifteen patients in the AFP response group had tumor progression and 14 died, the disease control rate was 61.1%,while 21 patients in the AFP non-response group had tumor progression and 18 died,.the disease control rate was 51.8%. The median time to overall survival time was 13.5 months and 8 months(P<0.05) in AFP response group and AFP non-response group, respectively. Multivariate analysis showed that AFP response,cirrhosis,TNM stage and venous invasion were independent predictors of shorter overall survival time. Hand-foot syndrome, related gastrointestinal tract reaction and alopecia were the first three side effect events. Conclusion〓AFP response may be considered as an alternative marker for capture sorafenib activity in HCC. Cirrhosis, TNM stage and venous invasion maybe consider as another possible predict factor to sorafenib in advanced HCC patients.

The relationship of Tau protein expression with the sensitivity in taxane chemotherapy of recurrent and metastatic breast cancer

Zhou Jie, Tan Xiaojun, He Weixing, Han Guodong, Chen Guiquan, Li HongSheng

2014, 14(02):  153-156.  DOI: 10.3969/j.issn.1009-976X.2014.02.011

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【Abstract】〓Objective〓To investigate the expression of Tau protein in recurrent and metastatic breast cancer and the correlation between Tau protein and the effect of taxane-containing palliative chemotherapy. Methods〓The expression of Tao protein in the metastatic breast tumor tissue of 136 patients with recurrent and metastatic breast cancer was detected by immunohistochemistry.The correlation between the expression of Tao protein and clinical variables, such as taxane sensitivity and the associations between Tau expression and the efficiency of taxane-containing palliative chemotherapy was used by χ2 test or Fisher exact probability test. Results〓The expression of Tau protein in thirty-nine (28.68%, 39/136) patients was positive. The expression of Tau protein was positively related to ER (P<0.05) and negatively related with the effect of taxanes-containing palliative chemotherapy (P<0.01). Conclusion〓The expression of Tau protein was negatively related with the effect of taxane-containing palliative chemotherapy. The detection of the expression of Tau protein in recurrent and metastatic breast cancer may be a clinical basis to choose taxane-containing palliative chemotherapy.

Analysis of diagnosis and treatment in the upper urinary tract obstruction associated with chronic nonbacterial cystitis

Li Kai, Zhong Ming, Yuan Mingsheng, Tang Shunli, Xiong Tao, Huang Mingzhi,

2014, 14(02):  157-159.  DOI: 10.3969/j.issn.1009-976X.2014.02.012

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【Abstract】〓Objective〓To investigate nonbacterial cystitis in the upper urinary tract obstruction. Methods〓137 cases with upper urinary tract obstruction were included in the study. Chronic nonbacterial cystitis was confirmed by mid-stream urine culture(MSU), cystoscopy, biopsy, and ureteroscopy. The incidence, diagnosis and treatment of nonbacterial of nonbacterial cystitis were investigated retrospectively. Results〓Thirty-two cases of chronic nonbacterial cystitis were found in 137 cases with upper urinary tract obstruction(23.4%), in which 27 cases were caused by upper urinary lithiasis obstruction(19.7%), 5 cases by non-calculus obstruction(3.6%). Of 32 cases,glandular cystitis had 23 cases, proliferative cystitis 3 cases, vesical leukoplakia lesion 6 cases. Moreover, the nonbacterial cystitis was complicated with chronic ureteritis and ureteral polyps in 11 cases. In the nonbacterial cystitis cases, MSU was positive in 3 cases (all caused by Escherichia coli), while in 96 cases without nonbacterial cystitis, MSU was positive in 11 cases, including 10 cases of E.coli infection, one of staphylococcus aureus infection and one of staphylococcus epidermidis infection..Sixteen nonbacterial cystitis patients were followed up for 3 months post-treatment of relief of obtrucion..The patient got recovery. Conclusion〓The upper urinary tract obstruction may be associated with high incidence of nonbacterial cystitis.

The risk of prosthetic mismatch after transcatheter aortic valve implantation:a meta analysis

Wang meng, Fu Ganglan, Jiang Huiqi, Zeng Kuan, Hua Ping, Xu Zhongdong

2014, 14(02):  160-164.  DOI: 10.3969/j.issn.1009-976X.2014.02.013

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【Abstract】〓Objective〓Prosthesis-patient mismatch (PPM) leads to increased left ventricle afterload and influences the clinical outcome of postoperative patients. This Meta analysis aims to study risk factors of prosthesis-patient mismatch (PPM) after transcatheter aortic valve implantation (TAVI). Methods〓The data of prosthesis-patient mismatch after transcatheter aortic valve implantation was derived by searching Medline, Cochrane library, Scopus database. Studies with baseline data of PPM group and no PPM group were included in the Meta analysis. Results〓PPM patients had averaged body surface area of 1.87±0.202 m2,.age of 78.3±7.78 years old,.left ventricle ejection fraction of 41.0±14.1%,.effective orifice area index of 0.366±0.0922..Comparing with no PPM group,.PPM patients had larger body surface area,.lower left ventricle ejection fraction and lower effective orifice area (P<0.05)..No significant statistical differences of the other factors were found,.including sex,.body metabolic index,.preoperative acute myocardial infarction,history of coronary artery bypass graft,.NYHA grade,logistic EuroSCORE,transvalvular gradient,aortic annulus diameter(P>0.05). Conclusion〓Larger body surface area,lower left ventricle ejection fraction and more severe aortic stenosis are related to PPM.

Repair of scalp defect by using free anterolateral femoral arterial perforating branches flap

Hong Xiaofang, Meng Hong, Huang Jianhua, Zhang Ganlin, Liu Xiaotao, Liu Weiyong

2014, 14(02):  165-167.  DOI: 10.3969/j.issn.1009-976X.2014.02.014

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【Abstract】〓Objective〓To discuss clinical experience in the repair of defect of scalp using free anterolateral femoral arterial perforating branches flap. Method〓From Jan 2010 to Jun 2013, complicated scalp defects in 21 patients were repaired with free anterolateral femoral flaps..Cutting off the anterolateral femoral flap,.the lateral femoral circumflex arterial main trumk of descending branches and its accompanied veins were anastomosed to the superficial temporal artery and veins to repair defect of scalp. Results〓The postoperative follow?鄄up was one to two years and the texture and color of flap were good..The size of flaps were 5cm?鄄13cm×8cm?鄄20cm and the mean was 6.7cm×17cm. Vascular crisis was happened in 1 case and the crisis was removed successfully after surgical exploration and re?鄄anastomosis. Conclusion〓The femoral anterolateral perforating branches were gross and its blood supply is reliable. The diameter of the descending branches of the femoral anterolateral artery is closed to superficial temporal artery and veins,which make this free perforating branches flap as a good choice of reconstruction of scalp defect due to trauma or tumor resection.

TriVex therapy in treatment of excessive axillary hair on women associated with bromhidrosis

Cui Dongming, Xiao Guanghui,Li Jinyou

2014, 14(02):  168-169.  DOI: 10.3969/j.issn.1009-976X.2014.02.015

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【Abstract】〓Objective〓To discuss clinical effect of Trivex therapy in treatment of excessive axillary hair on women associated with bromhidrosis. Methods〓Eighty female patients with excessive axillary hair associated with bromhidrosis were treated by using Trivex therapy. The clinical effect was evaluated. Results〓The operation time was 25-30 min and odor of bromhidrosis disappeared after operation. Subcutaneous hydrops and subcutaneous hematoma occurred in four cases and one case respectively. The recurrences were in five cases after one-year follow-up in which four were retreated with Trivex and recovery, one case abandoned treatment. Conclusion〓Effect of Trivex therapy in treatment of excessive axillary hair on women associated with bromhidrosis is satisfying, and suitable for young female patients due to scar-free healing.

Operation for correction of congenital double lip

Yao Yuanyuan,Liang Weiqiang,Chen Yuhong,Ji Chenyang,Zhang Jiaqi,Zhang Jinming

2014, 14(02):  170-172.  DOI: 10.3969/j.issn.1009-976X.2014.02.016

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【Abstract】〓Objective〓To investigate the surgical technique and effect of congenital double lip therapy. Methods〓From April 2005 to December 2010, surgical excisions of the hypertrophic mucosal tissue and mucous glands were performed on 9 patients with congenital double lip by a fusiform incision with sharp tips, under infraobital nerves block and local infilatration anaesthesia, and the wound was closed with interrupted sutures. Results〓All patients healed well, no complications occur, and double lips were corrected thoroughly. Followed up for 6-24 months, no signs of replace, minimal scar formation, and symmetric, satisfactory appearances were acquired. Conclusions〓Excisions of the hypertrophic mucosal tissue and mucous glands by a fusiform incision with sharp tips to correct congenital double lip is a safe and efficient technique with easy procedure, few complications and satisfactory results.

Application of mask bi-level positive airway pressure non-invasive ventilation in laparoscopic cholecystectomy

Zhao Ziliang, Gong Ting, Yu Ge, Weng Xiaohui

2014, 14(02):  173-176.  DOI: 10.3969/j.issn.1009-976X.2014.02.017

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【Abstract】〓Objective〓To investigate the feasibility and safety of mask bi-level positive airway pressure (BiPAP) non-invasive ventilation in the laparoscopic cholecystectomy under general anesthesia. Methods〓Forty cases of laparoscopic cholecystectomy were randomly enrolled into mask BiPAP ventilation group (group I) and endotracheal intubation intermittent positive pressure ventilation (IPPV) group (groupⅡ) with 20 patients in each group. Mean blood pressure (MAP), heart rate (HR), pulse oximetry (SpO2) and Narcotrend Index (NI) were monitored and recorded during operation at the time points as following: before anesthesia (T0), after induction of anesthesia (T1), after the mask or intubation (T2), mechanical ventilation post 5 minutes (T3), pneumoperitoneum post 5 minutes (T4), the end of surgery (T5), and after remove the mask or endotracheal tube (T6). Blood gas analysis was performed at T0, T3, T4, T5 to record PaO2, PaCO2 and PH values. Results〓MAP and HR in group I at time points T2 and T6 were lower than that in groupⅡ (P<0.05), while NI in group I at T1 point was higher than that in group Ⅱ (P<0.05). Meanwhile, MAP and HR at T2 and T6 point were significantly higher than those other time points in group Ⅱ(P<0.05), However, no difference was noted in group I. There was no significant difference in PaO2, PaCO2 or pH value at T0, T3, T4, T5 time points between the two groups. Conclusion〓BiPAP mask non-invasive ventilation in laparoscopic cholecystectomy under general anesthesia was safe and feasible through which the effective ventilation and stable dynamics can be maintained.

Comparative study on the laparoscopic inguinal hernia repair and open inguinal hernia repair

hi Jinglong, Chen Haisheng, Chu Zhonghua

2014, 14(02):  176-178.  DOI: 10.3969/j.issn.1009-976X.2014.02.018

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【Abstract】〓Objective〓To compare the efficacy between laparoscopic inguinal hernia repair and open inguinal hernia repair. Methods〓From May 2012 to May 2013, 240 cases of adult inguinal hernia repair were retrospectively analyzed. Of 240 cases,148 cases underwent open herniorrhaphy (open group), 92 underwent laparoscopic herniorrhaphy (laparoscope group). The clinical parameters of two groups were recorded and analyzed,including operation time,.length of hospital stay, hospital expenses,.postoperative recurrence,.postoperative chronic pain,.postoperative scrotal hydrops and postoperative infection. Results〓The average operation time and hospitalization expenses for open group was 62.9±9.8 min and 8420±2481 yuan,.lower than that laparoscopic group (76.2±9.4 min and 12468±33858 yuan,P<0.01). However, postoperative complications in open group were including recurrence (3 cases), chronic postoperative pain(11 cases), postoperative scrotal hydrops (2 cases), postoperative infection (1 case) were higher than that in laparoscopic group (P<0.05). No difference was found in hospital stay between two groups. Conclusion〓Laparoscopic hernia repair has less postoperative complications,.shorter hospitalization time,.but has more hospital expenses.

Experience endoscope-assited thyroidectomy(A report of 105 cases)

Li Peng, Yuan Min, Wang Donglai, Hu Hui, Yu Zhiqiang, Wei Wei

2014, 14(02):  179-181.  DOI: 10.3969/j.issn.1009-976X.2014.02.019

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【Abstract】 Objective〓To report our excrience from minimally invasive video-assisted thyroide-ctomy(MIVAT) and analyze the characteristic and indication of MIVAT. Methods〓A total 105 cases with benign thyroid goiter were included this study. The incision length, incision location, operation time and complications were summarized and analyzed. Results〓105 cases of MIVAT were successfully accomplished..The average operation time was 65.5 min among the 65 patients with unilateral thyroidectomy,.and 112.4 min for the 40 cases of bilateral thyroidectomy..The lengths of operation incision were from 2.0 cm to 3.5 cm, the average of 2.7 cm. No hematoma occurred. Two patients felt numbness at the next day after operation, 1 case had hoarseness, and 1 patient had a deep voice. All of them were given symptomatic treatment and recovered in 1 month follow-up. Conclusion〓The characteristic of MIVAT was minimally invasive,.cosmetic apperence and more comfortable,.furthermore, it could reduce the postoperative complication.

Treatment of high risk benign prostatic hyperplasia by bipolar transurethral plasma kinetic resection of the prostate in 97 cases

Li Jian, Zheng Minli, Huang Yuqing, Feng Lingsong, Huang Minzhi, Zou Huoshe

2014, 14(02):  182-185.  DOI: 10.3969/j.issn.1009-976X.2014.02.020

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【Abstract】〓Objective〓To assess the clinical efficacy and safety of bipolar transurethral plasma kinetic resection of the prostate (TUPKP) for treatment of high risk patients with benign prostatic hyperplasia (BPH). Methods〓The clinical data of 97 symptomatic BPH patients who underwent transurethral enucleate resection of prostate (TUERP) and TUPKP were retrospectively analyzed. 51 cases and 46 cases were performed by the methods of TUERP and TUPKP respectively. Results〓The mean operation time was (51.3±22.1) min. The volume of blood loss was (62.4±16.2) mL. The mean weight of resected prostate glands was (66.3±18.5) g. The washing time after operation was (36.1±10.3) h; and the extubating time was (5.0±1.5) d. The international prostate symptom score (IPSS) decreased from 26.6±4.5 to 6.8±3.5.Quality of life decreased from 5.9±1.3 to 1.8±0.6, and all the differences were significant (P<0.01). Conclusion〓TUPKP were effective and safe to deal with the patients with BPH in high risk, but proper individual operation method (TUERP or TUPKP) should depend on the specific circumstances of the patients.

Acute urinary retention increases the risk of early complications of patients after transurethral resection of the prostate

Luo Xin, Yang Xiang, Lin Yufeng, Li Jiexian,Chen Fengtin, Xie Wenlian

2014, 14(02):  186-189.  DOI: 10.3969/j.issn.1009-976X.2014.02.021

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【Abstract】〓Objective〓To investigate the early postoperative complications after transurethral resection of prostate (TURP) in patients with acute urinary retention (AUR). Methods〓The clinical data of patients with benign prostatic hyperplasia (BPH) and with or without AUR were analyzed retrospectively from January 2010 to December 2011. All patients with or without AUR underwent TURP [AUR (+) groups, n=144, AUR (-) groups, n=116]). The early postoperative complications were compared between two groups,including urinary tract infection (UTI),hematuria,re-catheterization, urinary incontinence, shock, blood transfusions, septicemia and lower urinary tract symptoms (LUTS). Results〓The AUR(+) group had more UTIs (45.83% vs 10.34%, OR:7.33, 95% CI: 3.71-14.50), more hematuria (19.4% vs 6.9%,OR:3.25,95% CI:1.41-7.50) and more re-catheterization (8.33% vs 2.59%, OR: 3.42, 95% CI: 0.94-12.44). Urinary incontinence (1.39%), shock (0.69%) and blood transfusions (4.17%) were found only in the AUR (+) group. There were no statistical significance of LUTS and septicemia in both groups. Conclusion〓The patients with AUR have a higher risk of early postoperative complications.

Comparison of curative effects between laparoscopic cholecystectomy and open cholecystectomy in elderly patients with acute cholecystitis

Tan Jianzhi, Zeng Lianhua, Chen Xijian, Liu Zhengxiang

2014, 14(02):  189-192.  DOI: 10.3969/j.issn.1009-976X.2014.02.022

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【Abstract】〓Objective〓To compare the effects between laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) for acute cholecystitis in elderly patients. Methods〓From January 2007 to December 2012,76 cases over 70 years old with acute cholecystitis were included in this study. Among them, 34 underwent LC (LC group) and 42 underwent OC (OC group). The operating time, blood loss, postoperative hospital stay and complications were analyzed between two groups. Results〓All operations were completed successfully without conversion to open surgery in LC patients. Operating time in LC group was 95.2±19.7 min and 86.8±21.2 min in OC group. There were two patients in LC group with blood loss more than 500 mL and eight patient in OC group(P<0.05). Mean postoperative hospital stay in LC group was significantly shorter than that in OC group (P<0.01). There were 24 cases of postoperative complications (31.6%), the complications in LC group was also less than that in OC groupa(P<0.05). Conclusion〓Laparoscopic cholecystectomy could shorten postoperated hospital stay and reduce complications.

Analysis of hernia repair for patients with hepatitis B complicated by cirrhosis and ascites in 28 cases

2014, 14(02):  193-195.  DOI: 10.3969/j.issn.1009-976X.2014.02.023

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【Abstract】〓Objective〓To summarize the experience of tension-free hernioplasty for the chronic hepatitis B patients with cirrhosis and ascites. Methods〓From June 2006 to June 2011, 28 cirrhotic patients complicated by inguinal hernia underwent tension-free hernia repair in our hospital. The clinical data were retrospectively analyzed including the preoperative and postoperative treatment, surgical timing and surgical method. Results〓All operations were successfully completed and operative incisions were first intention. The operative complications included slight hematocele, wound oozing of blood, wound extravasation (from abdominal fluid) in one case, respectively. The follow-up ranged from 18 to 78 months, no infection and no recurrence were found. Conclusion〓For the patients with Hepatitis B complicated by cirrhosis and ascites, it is necessary to perform a strict perioperative management for receiving hernia repair and improving the quality of life

Comparison of the therapeutic effect between early minimally invasive craniopuncture drainage and small bone flap craniotomy for removing the hematoma in hypertensive cerebral hemorrhage

Yu dachao, Huang Ming

2014, 14(02):  195-198.  DOI: 10.3969/j.issn.1009-976X.2014.02.024

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【Abstract】〓Objective〓To evaluate the curative effect between early minimally invasive craniopuncture drainage and small bone flap craniotomy for removing the hematoma in hypertensive cerebral hemorrhage. Methods〓The clinical data of 98 patients with hypertensive basal ganglia hemorrhage were retrospectively analyzed. The patients were divided into minimally invasive hematoma removal surgery group (minimally invasive group, n=63 cases) and small bone flap craniotomy hematoma removal group (small bone flap craniotomy group, n=35 cases). Operation time, hospitalization stay and awareness recovery of patients were evaluated. The neurologic deficit (NID) and the activities of daily living (ADL) were measured at 1 and 3 months after operation respectively. Results〓The operation time and hospitalization stay in minimally invasive group were less than that in small bone flap craniotomy group. No statistical difference was observed in the time of awareness recovery of patients between two groups. One month after treatment, the NID of minimally invasive group was significantly lower than that of the small bone flap craniotomy group. The patient self-care ADL of minimally invasive group was better than that of the small bone flap craniotomy group at the third month. Conclusion〓Minimally invasive puncture has an advantage over small bone flap craniotomy in the operation time, hospitalization stay, reduction of neurological deficit and recovery of daily living activities.

Clinical application of minimally invasive Mammotome Biopsy system in nonpalpable breast lesions

Chen Xiaoming, Zhen Lefeng, Zhong Feng, Hu Xuesheng, Wang Jinzhong

2014, 14(02):  199-201.  DOI: 10.3969/j.issn.1009-976X.2014.02.025

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【Abstract】〓Objective〓To evaluate the clinical application of ultrasound-guided minimally invasive Mammotome Biopsy system in nonpalpable breast lesions. Methods〓The surgical treatment for 85 nonpalpable breast lesions in 62 patients were performed by ultrasound-guided minimally invasive Mammotome Biopsy system. Result〓All lesions were resected accurately and completely. Via intraoperative frozen section, benign lesions and breast cancer were found in 77 and 8 cases respectively. All results of intraoperative frozen section were consistent with the result of postoperative paraffin section. Three months after surgery, patients were followed by ultrasound examination. None of them had local recurrences. Conclusion〓The ultrasound-guided minimally invasive Mammotome Biopsy system is an effective method for the diagnosis of nonpalpable breast lesions. And it would also resect the benign lesions accurately and completely.

Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus

Zhang Jindai, Chen Jie, Ye Yibiao, Wu Xiao, Chen Tao

2014, 14(02):  202-206.  DOI: 10.3969/j.issn.1009-976X.2014.02.026

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【Abstract】〓Portal vein tumor thrombosis (PVTT) is one of the most important prognostic factors for survival in patients with hepatocellular carcinoma (HCC). Patients with PVTT have significantly worse outcomes after treatment. There is no consensus about the optimal treatment for such patients. To improve on the results of treatment of HCC with PVTT, various methods have been applied, such as transarterial chemoembolization, systematic treatment with drugs, radiofrequency ablation therapy and hepatic resection. However, the results are not so encouraging. With the development of surgical techniques and new drugs, a good prognosis would be achieved with combined treatments.

Advance in gene-targeted therapy for colorectal cancer

Zhong Lin, LI Qiang, Chen Fei, Zou Zhaowei, Zheng Wei, Huang Zonghai

2014, 14(02):  207-210.  DOI: 10.3969/j.issn.1009-976X.2014.02.027

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【Abstract】〓Colorectal cancer is a common digestive tract cancer. Although the comprehensive treatments with primary surgery integrated with chemiotherapy or radiotherapy, the postoperative 5-year survival rate has not been improved evidently (about 50%). In recent years, gene therapy for colorectal cancer has attracted much attention, nd many research results have been applied in Clinical. Currently, the main methods include proto-oncogenes therapy, tumor suppressor therapy,immunotherapy ,complex gene therapy and so on.

Research advances in the peripheral nerve metastasis of malignant tumors

Guo Yubo, Zeng Linjuan, Su Hong, Huang Kaihong

2014, 14(02):  211-213.  DOI: 10.3969/j.issn.1009-976X.2014.02.028

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【Abstract】〓Perineural invasion (PNI) has been reported to be closely related to the metastasis and recurrence in various cancers..For many of these malignancies,.PNI is emerging as an independent risk factor for poor prognosis. In the present study, a clear definition of PNI was laid out, and then the authors summarized current theories on the molecular mechanism and pathogenesis of PNI. In addition, current research in vitro and in vivo models for PNI were also introduced. The objectives of this review were to highlight the PNI status in predicting cancer metastasis and recurrence, as well as lead to advancements in the understanding and target therapy of this pathological entity.

Progresses in DC-CIK adoptive cellular immunotherapy in treatment of hepatocellular carcinoma

Zu Yuqi, Xue Pin

2014, 14(02):  214-216.  DOI: 10.3969/j.issn.1009-976X.2014.02.029

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【Abstract】〓Hepatocellular carcinoma (HCC) is the most common malignant tumor in China. HCC is difficult to find and confirm in early stage. Most of patients were in advanced stage when the symptom or signs were presented.The various treatments of HCC,.such as liver resection, transplantation, local ablation, chemotherapy, and molecular targeted therapy, have not improved the 5-years survival rate efficiently. Cell-based therapies is now gaining more and more attention since some success have been achieved, and DC combined CIK cells therapy is one of these attempts. DC and CIK cells are two important factors for cancer immunotherapy..The interaction between them and induced immune response are important parts of the treatment. The advance of DC-CIK cell therapy for HCC is reviewed in this paper.