Abstract: Department of Hepatic Surgery，Guangzhou First People′s Hospital，Guangzhou 510180，China Objective To evaluate the three different intravenous injections for the determination of liver function. Methods We selected 100 patients with internal jugular vein catheter to assess liver function by indocyanine green （ICG） injection. Each patient received all three different kinds of intravenous drug injection method respectively for testing. Then we compared three methods of determination on K and R15 values to check if they have significant difference statistically. Method one：liquid medicine was pushed by injection with the cubital vein indwelling needle followed with the pipe saline washing immediately ；Method 2 ：the volume of liquid medicine was increased by 0.4 mL with cubital vein indwelling needle without pipe saline washing. Method three：medicine injection was through the jugular vein pipe without pipe saline washing. Results The K and R15 values showed no significant difference statistically among three methods. The peak of blood concentration of Method 3 occurred earlier ，but not affect the final test results. Conclusion The three intravenous injection methods for the determination of liver function can successfully complete the administration process，and their results were close to the data，but the central venous catheter was better.

Key words: determination of liver reserve function, K value, intravenous injection, R15

摘要： 目的 比较肝储备功能测定中三种不同的静脉注药方法，合理选取最佳方法，达到简化流程，节约成本，提高检测准确性的目的。方法 选取肝脏术后停留中心静脉导管并需进行肝储备功能测定的患者 100 例，每名患者都按照三种不同的静脉注药方法进行检测，比较三种测定方法得到的K 和R15 值有无统计学差异。方法一，在肘静脉留置针推注药液后立即予生理盐水冲管；方法二，药液量增加留置针管道的容量 0.4 mL，经肘静脉留置针推注后无须冲管；方法三，经中心静脉导管推注药液，不冲管。结果 三种方法得到的K 值和R15 值均无统计学差异；方法三血药浓度峰值出现时间更早，但并不影响最终检测结果。结论 肝储备功能测定的三种静脉注药方法均可顺利完成给药过程，结果数据接近，但采用中心静脉导管给药效果更好。

关键词: R15, 静脉注射, K 值, 肝储备功能测定