Abstract: Objective To investigate the clinical value of cryoablation and cold tip radiofrequency ablation（RFA）in the treatment of malignant liver tumors. Methods Ultrasound guided cryoablation with argon?helium knife was performed in 38 patients with 42 lesions，and ultrasound?guided RFA was performed in 40 patients with 44 lesions.Before and after treatment ，contrast enhanced ultrasound ， enhanced CT or enhanced MRI examination were used to confirm the diagnosis and evaluate the curative effect. Results 32 lesions were completely ablated after one?time cryoablation，10 lesions were completely ablated after another?time cryoablation，33 lesions were completely ablated after one?time RFA，and 11 lesions were completely ablated after another?time RFA. The total ablation rate was 76.2%（cryoablation） and 75%（RFA）respectively，and the difference was not statistically significant. Conclusion Argonhelium cryoablation and cold?circulating RFA can effectively inactivate liver cancer in situ ，which is one of the effective non?surgical methods for the treatment of malignant liver tumors.

Key words: liver cancer, argon helium cryoablation, radiofrequency

摘要： 目的 探讨氩氦刀冷冻消融与冷循环射频消融（cool-tip radiofrequency ablation，RFA） 在恶性肝肿瘤治疗中的临床应用价值。方法 超声引导下氩氦刀冷冻消融治疗肝癌 38 例共 42 个病灶；经超声引导下 RFA 治疗肝癌 40 例共 44 个病灶，治疗前后经超声造影、增强 CT 或增强MRI 检查明确诊断及评价疗效。结果 42 个病灶经一次冷冻消融治疗后32 个达完全消融，10 例经再次冷冻消融后达到完全消融；44 个病灶经一次RFA 治疗后完全消融33 个，11 例经再次RFA后达到完全消融。两者一次完全消融率分别为 76.2%（冷冻消融）和 75%（RFA），差异无统计学意义。结论 氩氦刀冷冻消融和冷循环RFA 均能有效地原位灭活肝癌细胞，是有效的非手术治疗恶性肝肿瘤的方法之一。

关键词: 射频消融, 氩氦刀冷冻消融, 肝癌