Abstract: ［Abstract］ Colorectal cancer（CRC）is the third most common malignancy in the world and the fourth leading cause of cancer-related deaths. Circular RNAs are novel long-chain non? coding RNAs that are widely present in eukaryotes and are spliced by a variety of mechanisms. Early circular RNAs were ignored as a by?product of gene expression and had no biological function. Recent studies have confirmed that circular RNAs play an indispensable role in many life activities and that abnormal expression in CRC tissues plays a significant role in proliferation，invasion，metastasis and apoptosis of the tumor cells. Exploring the mechanism of action of the circular RNA in colorectal cancer will contribute to the early diagnosis，treatment and prognosis of CRC. This article will focus on the latest research progress of circular RNA in colorectal cancer，thus providing new ideas for the diagnosis and treatment of CRC.

Key words: colorectal cancer, circular RNAs

摘要： ［摘要］ 结直肠癌（CRC）是全球第三大常见的恶性肿瘤，也是导致癌症相关死亡的第四大原因。环状 RNA 属新型长链非编码 RNA，广泛存在于真核生物中，由多种机制剪接而成。早期被当成基因表达的副产物且无生物学功能而被忽略。近年研究证实环状 RNA 在许多生命活动中发挥着不可或缺的作用，并且在 CRC 组织中存在差异表达，对肿瘤细胞的增殖、侵袭、转移和凋亡发挥着重要作用。探索环状 RNA 在结直肠癌中的作用机制，将有助于 CRC 的早期诊疗和预后。本文将针对结直肠癌相关环状RNA 的最新研究进展做一阐述，以期为CRC 的诊治提供新的思路。

关键词: 环状RNA, 结直肠癌