Abstract: ［Abstract］ Objective To determine the cooperative effect of LMH and intravenous infusion of butylphthalide on the treatment of 32 patients with cerebral infarction. Methods Nine-four cases with cerebral infarction after the micro-invasive surgery were randomly divided into 3 groups. Clinical outcomes and Ischemia volume were assessed. Results Compared with LMH group and butylphthalide group，NIHSS scores in cooperative treatment group were significantly decreased respectively at 14?day and 30-day. Compared with LMH group and butylphthalide group，hematoma volume in cooperative treatment group was significantly decreased at 3? day. Compared with LMH group，hematoma volume in cooperative treatment was markedly decreased at 7?day. Compared with LMH group，ischemia volumes in other 2 groups were significantly decreased at 14-day. Conclusions Combined LMH therapy and survival in the ischemic penumbra region.

Key words: hypertension?induced cerebral hemorrhage, cerebral infarction, local mild hypothermia therapy, intravenous infusion of butylphthalide

摘要： ［摘要］ 目的 观察亚低温联合丁苯酞注射液治疗高血压脑出血微创血肿清除术后继发性脑梗死的临床疗效。方法 选择高血压脑出血微创血肿清除术后继发脑梗死患者94 例，按不同治疗方式随机分为亚低温组29 例、丁苯酞组33 例和联合治疗组32 例、。采用NIHSS 评分法评估三组治疗前及治疗后 7 天、14 天、30 天的临床疗效，同时对比三组治疗前及治疗后第 3 天、7 天、14 天的缺血灶大小。结果 治疗 7 天后，三组 NIHSS 评分差异无统计学意义（P>0.05）；治疗 14 天、30 天后，联合治疗组 NIHSS 评分较亚低温组和丁苯酞组均显著降低（所有 P<0.01），而亚低温组和丁苯酞组NIHSS 评分差异无统计学意义（所有 P>0.05）；治疗3 天后，联合治疗组缺血灶大小较亚低温组和丁苯酞组明显减少（所有 P>0.05）；而亚低温组和丁苯酞组缺血灶大小减少差异无统计学意义（P>0.05）。治疗7 天后，联合治疗组缺血灶大小较亚低温组明显减少（P<0.01）；治疗14天后，联合治疗组缺血灶大小较亚低温组明显减少（P<0.01），丁苯酞组缺血灶大小较亚低温治疗组也明显减少（P<0.05）；但联合治疗组和丁苯酞组缺血灶大小减少差异无统计学意义（P>0.05）。结论 早期亚低温联合丁苯酞注射液治疗能显著减小高血压脑出血微创血肿清除术后继发脑梗死患者的缺血灶体积、降低NIHSS 评分。

关键词: 高血压脑出血, 继发脑梗死, 亚低温, 丁苯酞注射液