Abstract: ［Abstract］ Spinal cord injury（SCI）is a common type of trauma in transportation, labor and sportsaccident. It is a serious disabling injury, leading to physical dysfunction of the corresponding body innervated by the damage segmental spine. However, secondary injuries induced by SCI are the key in the treatment, so we should focus on therapies of secondary injuries. Traditionally, surgery or drugs are the main ways to alleviate the secondary injuries, but as the understanding of biological mechanism has become more and more profound, some drugs or stem cell therapies have shown great potential in the treatment. It will provide a new sight and hope to cue SCI. This article is underlying the pathophysiology of SCI and the developing drugs and therapeutic ways to treat SCI in recent years.

Key words: spinal cord injury, pathophysiology, non?surgical treatment

摘要： ［摘要］ 脊髓损伤是交通、劳动和运动意外事故中常见的创伤类型，是一种严重的致残性损伤， 往往导致损伤节段以下肢体功能严重障碍。导致脊髓损伤难以治疗的关键是继发性损伤，所以如何治疗继发性损伤成为治疗脊髓损伤的重点。脊髓损伤的治疗主要是通过手术或者药物缓解脊髓损伤引起的继发性损伤。随着对生物机理的认识越来越深刻，一些药物或者干细胞疗法在治疗脊髓损伤表现出巨大的潜力，这将为治疗脊髓损伤提供新的视野和希望。本文就脊髓损伤病理生理，以及一些近年来出现的治疗脊髓损伤新的药物及手段做综述。

关键词: 脊髓损伤, 病理生理, 非手术疗法