Abstract: Objective To investigate the expression level and clinical significance of special AT-rich sequence binding protein 1（SATB-1）and α-smooth muscle actin（α-SMA）in pancreatic cancer. Methods Immunohistochemical staining was performed to analyze the expression of SATB- 1 and α- SMA in 71 pancreatic cancer tissue, the clinicopathological features were collected, and the clinical relationship between the SATB-1 and α-SMA expression and clinicopathological features. Results The positive expression rate of SATB- 1 and α- SMA was 70.4% and 77.5%, respectively. Kaplan- Meier analysis showed that the expression levels of SATB-1 and α-SMA was relative with overall survival time of pancreatic cancer patients. Cox regression analysis showed that differentiation and SATB- 1 expression were independent prognosis factors of pancreatic cancer patients. Chi- square test showed that SATB- 1 expression was relative with the expression of α- SMA（P<0.05）. Conclusion SATB- 1 and α- SMA was over- expressed in pancreatic cancer, and SATB- 1 deserved as an independent prognosis factor of pancreatic cancer.

Key words: SATB-1, α-SMA, pancreatic cancer

摘要： 目的　探讨特异性富AT序列结合蛋白1（SATB-1）和平滑肌肌动蛋白-α（α-SMA）在胰腺癌中表达以及二者的临床意义。方法　运用免疫组化染色检测了71例胰腺癌组织中SATB-1和α-SMA表达情况,收集患者的临床病理特征,并分析二者与临床相关因素的关系。结果　SATB-1和α-SMA在胰腺癌中阳性率分别为70.4%和77.5%；Kaplan-Meier分析提示SATB-1和α-SMA表达与胰腺癌患者总体预后有关，Cox回归分析提示分化程度和SATB-1是影响胰腺癌患者预后的独立因素；卡方检测提示SATB-1和α-SMA二者的表达存在显著相关性（P<0.05）。结论　SATB-1和α-SMA在胰腺癌中高表达，且SATB-1可作为预测胰腺癌患者预后的独立因素。

关键词: 特异性富AT序列结合蛋白1, 平滑肌肌动蛋白-α, 胰腺癌