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Lingnan Modern Clinics in Surgery ›› 2017, Vol. 17 ›› Issue (04): 404-406.DOI: 10.3969/j.issn.1009-976X.2017.04.006

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Relationship between serum resistin and gastric cancer-associated cachexia

ZHAO Lixiang, CHEN Sizeng, WANG Jieshi, YAN Baogong, ZHENG Fangge   

血清抵抗素与胃癌恶病质的关系

赵理想 陈思曾 王结实 闫保功 郑方阁   

  1. 平顶山市第一人民医院
  • 通讯作者: 赵理想

Abstract:

Objective To observe the changes of serum resistin level in patients with gastric cancer associated-cachexia and to investigate the relationship between resistin and interleukin-6IL-6. Methods Twenty-three cases of gastric cancer patients with cachexia were assigned to the cachexia group; 23 cases of gastric cancer patients without cachexia were used as the gastric cancer group; and 23 healthy people were taken as normal controls. All the subjects were tested the sex, age, BMI and pathologic stages of cancer. The serum levels of IL-6, resistin were detected by enzyme-linked immunoabsorbent assay ELISA. Results Patients with pathologic stages and were more susceptible to cachexia than those with pathologic stages and in gastric cancerP< 0.05. Compared with control group, the serum resistin level and IL-6 were significantly increased in the cathexia group and gastric cancer groupP<0.05. Along with pathological stage increasing, the serum resistin level were significantly increased. Serum resistin level was positive correlated with IL-6 in the cachexia groupr = 0.512, P = 0.012. Conclusion Along with pathological stage increasing in gastric cancer, the serum levels of resistin and IL-6 were significantly increased. Serum resistin and IL-6 were increased in the cathexia patients. And serum resistin was positively correlated with interleukin-6 in gastric cancer cachexia.

Key words: resistin, IL-6, gastric cancer, cachexia

摘要:

目的 观察血清抵抗素与胃癌及胃癌恶病质的关系,并初步探讨胃癌恶病质中抵抗素与白介素-6相关性。方法 选取胃癌并恶病质患者23例为胃癌恶病质组,胃癌患者23例为胃癌组、健康成人23例为对照组。记录患者性别、年龄、BMI及肿瘤分期。采用ELISA法测定血清抵抗素和白介素-6水平(IL-6)。结果 期胃癌较期胃癌更易发生恶病质(P<0.05),与健康成人相比血清抵抗素、白介素-6在胃癌及胃癌恶病质中升高(P<0.05)。血清抵抗素水平随着胃癌病理分期的增加有逐渐升高趋势(P<0.05)。胃癌恶病质组血清白介素-6水平与血清抵抗素水平显著正相关(r=0.512P=0.012)。结论 血清抵抗素水平随着胃癌病理分期的增加逐渐升高,胃癌恶病质患者血清抵抗素的升高与白介素-6呈正相关关系。

关键词: 胃癌, 恶病质, 白介素-6 , 抵抗素

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