Abstract:

Objective To summarize up the experience in applying methylene blue dye to locate sentinel lymph nodes of cN0 thyroid papillary carcinoma. Mehtods Fifty?one patients of thyroid papillary carcinoma were performed sentinel lymph node biopsy by using methylene blue dye positioning. After Functional neck dissection ，the number of sentinel lymph nodes and cervical lymph nodes were recorded and analyzed. Results Among the 51 patients，46 cases were found to have blue?stain sentinel lymph nodes with a detection rate of 90.2% ，positive rate of 45.7% ，negative rate of 50% and false negative rate of 4.3%. The sensitivity was 91.3% （21/23），and the accuracy was 95.7% （44/46）. Conclusion Methylene blue as a tracer localizing sentinel lymph nodes on cN0 thyroid papillary carci? noma，evaluating the cervical lymphatic metastasis state ，and selecting surgical procedure，has the guid? ing significance.

Key words: methylen blue, SLN, cN0 thyroid papillary carcinoma

摘要：

目的 应用亚甲蓝示踪剂定位cN0甲状腺乳头状癌前哨淋巴结，探讨亚甲蓝定位前哨淋巴结的手术经验和技巧。方法 应用亚甲蓝作为前哨淋巴结示踪剂，对51例甲状腺乳头状癌患者进行前哨淋巴结活检术，同时常规行颈部功能淋巴结清扫术，统计前哨淋巴结及颈部淋巴结数量，结合术中冰冻及术后石蜡病理，分析前哨淋巴结及颈部淋巴结转移情况及其相关性。结果 51例患者中，共有46例发现蓝染的前哨淋巴结，前哨淋巴结检出率90.2%，阳性率45.7%，阴性率50%，假阴性率4.3%，灵敏度91.3%（21/23），准确度95.7%（44/46）。结论 亚甲蓝定位cN0甲状腺乳头状癌前哨淋巴结，对cN0甲状腺乳头状癌颈淋巴转移状态的判断，及手术方式的选择具有指导意义，临床上应严格掌握操作规则并灵活处理。

关键词: 亚甲蓝, 前哨淋巴结 , cN0 甲状腺乳头状癌