Abstract: 【Abstract】〓Objective〓To investigate the adverse reactions of diphtheria-pertussis-tetanus vaccine by muscle injection at less-than 90 degree of puncture. Methods〓This is a prospective study in which 933 with age feom 18 months to 24 months were divided in two groups, observation group (n=466) and control group (n=467). The vaccinee in observation group were treated by muscle injection at a vertical puncture way, while those in control group by muscle injection at less-than 90 degree of puncture way. The adverse reactions were recorded and analyzed. Results〓The adverse reactions occurred in 23 cases (23/466, 4.94%) in observation including fever in 11, and local red and swelling hard nodes induced by muscular injection in 12 cases. In control group, there were 44 cases of adverse reactions (44/467, 9.42%), fever in 24, and local red and swelling hard nodes induced by muscular injection in 20 cases. The difference between two groups had statistical significance(P=0.008). The FLACC scores in observation group were lower those in control group (P<0.05). Conclusion〓Carrying out the standard operating instructions of DPT vaccine is propitious to reduce the adverse reactions.

Key words: Adverse effecte, Diphtheria-pertussis-tetanus, Angle

摘要： 【摘要】〓目的〓观察不同注射角度注射无细胞百白破疫苗不良反应,提高接种质量。方法〓分析两组共933例接种百白破疫苗(DPT)的小儿,按照注射角度不同分为对照组(注射角度<90°斜行进针)和观察组(90°垂直进针),比较两种角度注射无细胞百白破疫苗后的治疗效果及不良反应。结果〓观察组不良反应发生率为4.94%,对照组不良反应发生率为9.42%,观察组小儿出现的不良反应率明显低于对照组(P<0.05);观察组中FLACC评分也明显低于对照组。结论〓严格执行DPT接种操作规程可减少不良反应发生。

关键词: 不良反应, 角度, 百白破疫苗