Abstract: 【Abstract】 Objective To investigate the expression and cinical significance of AKIP1 and P65 in breast carcinoma. Methods〓Eighty-nine tissue specimens of breast carcinoma and 30 tissue specimen of paraneoplastic mammary gland were selected and stained with immunohistochemistry with SP ways. The express disparity of AKIP1 and P65 were contrasted between breast carcinoma and paraneoplastic mammary gland. The correlation of AKIP1 expression and P65 expression with biological behavior of breast carcinoma and correlation of AKIP1 expression with P65 expression in breast carcinoma were analyzed. Results〓The expression of AKIP1(56.2%) was lower in breast carcinoma than in paraneoplastic mammary gland(93.3%,P<0.01). The expression of P65 (85.4%) was higher in breast carcinoma than in paraneoplastic mammary gland(55.0%,P<0.01). The expression of AKIP1 and P65 was negative correlation in breast carcinoma(r=-0.704, P<0.01). The expression of AKIP1 and P65 were discrepant in breast carcinoma with different differentiation and lymph node metastasis(P<0.01). Conclusion〓The expression of AKIP1 and over-expression of P65 in breast carcinoma tissue may be early and high malignant in breast carcinoma.

Key words: Breast carcinoma, AKIP1, P65, Immunohistochemistry

摘要： 【摘要】 目的 探讨乳腺癌组织中AKIP1和P65的表达及其临床意义。方法〓选择89例乳腺癌组织标本及60份癌旁组织,采用SP法免疫组化染色检测乳腺癌组织和癌旁组织的AKIP1和P65蛋白的表达;分析AKIP1和P65蛋白表达与乳腺癌组织生物学行为的相关性及乳腺癌组织中AKIP1和P65表达的相关性。结果〓乳腺癌组织中AKIP1的阳性表达率(56.2%)低于癌旁组织(93.3%,P<0.01),P65的阳性表达率(85.4%)高于癌旁组织(55.0%,P<0.01),乳腺癌组织中AKIP1和P65的表达呈现负相关关系(r=-0.704,P<0.01),不同病理分化和淋巴结转移乳腺癌组织中AKIP1和P65的表达存在明显差异(P<0.01)。结论〓乳腺癌组织中AKIP1失表达及P65过表达可能与乳腺癌的发生早及恶性高有关。

关键词: 乳腺癌, AKIP1, P65, 肿瘤分化, 免疫组织化学