Abstract: 【Abstract】〓Objective〓To evaluate the effects of different doses of dexmedetomidine during tracheal extubation after general anesthesia. Methods〓Ninety cases of patients received radical hysterectomy surgery under general anesthesia were collected and divided into 3 groups (n=30 each), control group,low-dose group and high-dose group. The low-dose group received 0.3 μg/kg dexmedetomidine. The high-dose group received 1 μg/kg dexmedetomidine. The control group received the equal doses of saline. Hemodynamic changes, narcotrend value, recovery time and incidence of agitation were recorded during tracheal extubation after general anesthesia. Results〓Compared with control group, MAP of the patients in high-dose group were lower, recovery time were longer, incidence of agitation were lower(P<0.05). The hemodynamic changes of the low-dose group were more stable than the control group,the incidence of agitation were lower, recovery time and extubation time were shorter in low-dose group(P<0.05). Conclusion〓Low-dose dexmedetomidine for general anesthesia can effectively reduce extubation hemodynamic changes and incidence of agitation, and can shorten extubation time.

Key words: Dexmedetomidine, General anesthesia, Extubation

摘要： 【摘要】 目的 比较不同剂量艾贝宁用于全身麻醉苏醒拔管期对患者的影响。方法〓90例择期行广泛全子宫切除术的全麻手术患者分为对照组、低剂量组、高剂量组,每组30例,低剂量组应用0.3 μg/kg艾贝宁,高剂量组应用1 μg/kg艾贝宁,对照组应用等量生理盐水,比较三组拔管期间血流动力学、Narcotrend值、苏醒时间、躁动评分。结果〓与对照组相比较,高剂量组应用艾贝宁10 min后直至拔管后MAP均较低、苏醒时间较长、躁动发生率低,差异有统计学意义(P<0.05)。低剂量组血流动力学平稳,苏醒及拔管时间短,躁动发生率较低,差异有统计学意义(P<0.05)。结论〓低剂量艾贝宁用于全身麻醉苏醒拔管期可减少血流动力学波动,减少躁动,缩短拔管时间。

关键词: 全身麻醉, 拔管期 , 艾贝宁