Abstract: 【Abstract】〓Objective〓To investigate the diagnostic value of serum amyloid A(SAA) by comparison between SAA and procalcitonin (PCT). Methods〓Sixty-eight patients with sepsis were included in the study and were divided into two groups according to final diagnosis, sepsis group and non-infectious origin of systemic inflammatory response syndrome group (SIRS group). Serum SAA and PCT levels were determined and evaluated diagnostic significance by receiver operating characteristic curves (ROC). Results〓The levels of serum SAA and PCT in septic patients were significantly increased than that in non-infectious SIRS patients (P<0.001). Areas under ROC of SAA and PCT in the diagnosis of sepsis were 0.773±0.057 in SAA, 0.938±0.026 in PCT (SAA versus PCT,P<0.05). The accurate diagnostic rate of SAA was 70.6% and PCT 85.3%, while there were significant difference between them. Conclusion〓SAA, PCT have a same value for diagnosis of sepsis, but the later has advantage over the former.

Key words: Sepsis, Serum amyloid A, Procalcitonin, Diagnosis

摘要： 【摘要】〓目的〓检测血清淀粉样蛋白A(SAA)并与降钙素原(PCT)比较,探讨其对急诊脓毒症患者早期诊断的价值,以指导临床诊疗。方法〓回顾性分析2013年7月至2014年12月我院急诊收治的68例符合纳入标准患者的临床资料,根据最终诊断分为脓毒症组和非感染性SIRS 组,比较两组间血清SAA和PCT含量,绘制诊断脓毒症的受试者工作曲线(ROC曲线)。结果〓脓毒症组患者血清SAA、PCT浓度显著高于非感染性SIRS组,差异有统计学意义(P<0.01)|SAA、PCT诊断脓毒症的ROC曲线下面积分别为0.773±0.057、0.938±0.026,两者有统计学差异(P<0.05)|SAA、PCT各自截断点的诊断准确率为70.6%和85.3%。结论〓SAA、PCT两项指标对早期诊断脓毒症均有一定的价值,PCT的诊断效能强于SAA。

关键词: 脓毒症, 血清淀粉样蛋白A, 降钙素原, 诊断