Abstract: 【Abstract】〓Objective〓To investigate the clinical efficacy and adverse reaction of different treatment methods for the progress of gastric cancer. Methods〓Sixty-six cases of advanced gastric cancer were chosen and divided into observation group (n=33) and control group (n=33). The patients in observation group were treated by SOX (S-1+oxaliplatin) chemotherapy. The controls were given FOX (oxaliplatin plus calcium folinate and fluorouracil) chemotherapy. The clinical efficacy, adverse reaction and survival time between two groups were compared between two groups. Results〓The effective percentage of observation group was 84.9% (28/33) and showed no significantly difference compared with that of the control group (24/33, 72.7%, χ2 =1.451, P<0.05). The side effects included granulopenia, thrombocytopenia, gastrointestinal upset, abnormal liver function. There was significant difference of the median survival times between two groups (t=7.733, P<0.05). Conclusion〓In the present study, S-1+oxaliplatin chemotherapy showed good efficacy, less adverse reactions.

Key words: Gastric cancer, Progression, Chemotherapy

摘要： 【摘要】 目的 探讨不同方案治疗进展期胃癌的临床疗效及不良反应。方法 选取66例进展期胃癌,分观察组及对照组,各33例,观察组行SOX(替吉奥+奥沙利铂)化疗,对照组给予FOX(奥沙利铂+亚叶酸钙+氟尿嘧啶),比较两组临床疗效、不良反应及生存时间。结果〓观察组临床有效率为28/33,84.9%,对照组为24/33,72.7%,二者差异无统计学意义(?字2=1.451,P>0.05);观察组治疗期间出现的毒副作用主要表现为中性粒细胞降低、血小板减少、胃肠道反应、肝功能异常、食欲下降等;观察组与对照组中位生存期分别为29.27±7.15个月和17.84±4.58个月,差异具有统计学意义(t=7.733,P<0.05)。结论〓替吉奥+奥沙利铂治疗进展期胃癌患者临床可取得较好的疗效。

关键词: 胃癌, 进展期, 化疗