Abstract: 【Abstract】〓Objective〓To evaluate the relationship between Substance P levels in the synovial tissue of the human knee joint and the severity of progression in patients with knee (osteoarthritis, OA) OA. Methods〓A total of 212 OA patients and 115 controls were enrolled in the study (control group). The symptomatic severity of OA was assessed by the Legusue grading system. The OA group was divided into 3 groups, Mild OA group (A1, n=57), Mediate OA group (A2, n=87), and Severe group (A3, n=50). The severity of pain was assessed by Western Ontario McMaster University Osteoarthritis Index (WOMAC). Synovia Substance P levels were measured by enzyme-linked immunosorbent assay (ELISA). Results〓The levels Substance P in the synovial tissue were significantly higher in OA patients compared with controls. Substance P levels were positively correlated with WOMAC-pain scores (r=0.265, P<0.05) and Legusue grades (r=0.785, P<0.05) in OA patients. Conclusion〓The raised substance P levels might act as an important indication in the pathogenesis of OA.

Key words: Osteoarthritis, Substance P, Synovia

摘要： 【摘要】〓目的〓探讨膝关节滑液中P物质水平在骨性关节炎(OA)发病机制中的作用及与OA患者病情严重程度、疼痛程度的相关性。方法〓2012年2月~2014年4月选取在我医院住院治疗或者门诊治疗的膝OA患者212例,诊断均符合美国风湿病学会(ARA)制定的OA分类标准。骨关节的严重程度采用Legusue分级系统评估进行评估并分组。轻度组(A1)75例,中度组(A2)87例,重度组(A3)50例。疼痛严重程度按WOMAC)疼痛评分系统评估。另选择115例来自本院健康体检者作为正常对照组。采用竞争性酶联免疫吸附试验分别测定滑液中P物质水平。结果〓滑液中P物质水平与骨关节炎患者WOMAC疼痛评分正相关(r=0.265,P<0.05)。滑液中P物质水平与Legusue等级之间正相关(r=0.785,P<0.05)。结论〓关节液中P物质的变化可作为OA病情活动的监测指标之一。

关键词: 骨性关节炎, P物质, 滑液