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Lingnan Modern Clinics in Surgery ›› 2015, Vol. 15 ›› Issue (02): 125-131.DOI: 10.3969/j.issn.1009-976X.2015.02.001

• 论文 •     Next Articles

C-reactive protein predicts pathologic complete response to neoadjuvantchemotherapy in breast cancer

Chen Yi, Guan Xiaofeng, Nie Yan, Gong Chang, Song Erwei   

  • Contact: Song erwei

C反应蛋白对乳腺癌新辅助化疗患者疗效评估的影响

陈怡 管小凤 聂燕 龚畅 宋尔卫   

  1. 中山大学孙逸仙纪念医院
  • 通讯作者: 宋尔卫

Abstract: 【Abstract】〓Objective〓To analyze the relationship between C reactive protein (CRP) and clinical pathobiiology factors before and after neoadjuvant chemotherapy. Methods〓This research retrospectively analyzed 215 patients, who were diagnosed as breast cancer in stage Ⅱ-Ⅲ, admitted in the Breast Cancer Department of our hospital and accepted NAC in January 2001 to June 2010. The relationship of CRP with clinicopathological characteristics as well as efficacy of prediction of pathologic complete response according to two different standards were statistically analyzed. Results Patients with pCR were in lower CRP value comparing with non-pCR patients. CRP reached a high efficacy in predicting pCR (the absence of all invasive disease in the breast tumor). Conclusion〓The protein level of CRP shows predictive value of pCR with neoadjuvantchemotherapy patients.

Key words: Neoadjuvant chemotherapy, CRP, Breast cancer

摘要: 【摘要】〓目的〓本研究旨在运用C反应蛋白(CRP)作为全身及肿瘤局部炎症反应的参数,分析其与新辅助化疗前后乳腺癌患者的临床病理生物学因素之间的关系及其对新辅助化疗疗效的影响。方法〓本研究回顾性分析了我院乳腺外科2001年1月至2010年6月确诊并接受新辅助化疗的Ⅱ-Ⅲ期乳腺癌患者共215例。按不同的病理完全缓解(pCR)标准分组(包括原发灶和淋巴结及仅包括原发灶),统计学分析CRP与新辅助化疗患者的临床病理特征及病理完全缓解(pCR)之间的关系。结果〓达到pCR的患者较非pCR患者的CRP均值更低(P=0.035和P=0.032),CRP对pCR(仅包括原发灶)有良好的预测价值(P<0.001)。结论〓新辅助化疗前CRP水平有助于预测新辅助化疗疗效。

关键词: 新辅助化疗, CRP, 乳腺癌

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