Abstract: 【Abstract】〓Objective〓To investigate the role of Narcotrend (NT) monitor on postoperative cognitive impairment in elderly patients with laparoscopic chloecystectomy (LC). Methods〓Sixty cases of elderly patients under general anesthesia for laparoscopic chloecystectomy were randomized into two groups, the control group (n=30) and the NT group (n=30) according to the patients with or without NT monitor. The dosage of remifentanil and sevoflurane during anesthesia, operative time, extubation time, recovery time and incidence of postoperative dysfunction were recorded and analyzed. Results〓The dosage of remifentanil and sevoflurane in NT group were significantly lower than that of the control group, the difference was statistically significant (P<0.05). The incidence of Postoperative cognitive dysfunction in 24 h after surgery in NT patients was significantly lower than that of the control group (P<0.05), but not in the seventh day after surgery (P>0.05). Conclusion〓Narcotrend monitor during general anesthesia is instrumental to accurately judge the depth of sedation and effectively reduce the incidence of postoperative dysfunction in elderly patients undergoing LC.

Key words: Narcotrend monitoring, Cognitive dysfunction, Postoperative complications

摘要： 【摘要】〓目的〓探讨Narcotrend(NT)监测指导下的精确麻醉深度控制在预防老年患者全身麻醉下腹腔镜胆囊切除术术后早期认知功能障碍的作用。方法〓选择ASAⅡ-Ⅲ级拟在静吸复合麻醉下行择期腹腔镜胆囊切除手术的老年患者60例,随机分为对照组和NT组,每组30例,比较两组患者麻醉药物的用量、苏醒时间以及术后早期认知功能障碍的发生率。结果〓与对照组比较,NT组麻醉药用量显著减少,患者苏醒时间显著缩短(P<0.05);两组患者术后认知功能障碍的发生率在术后第1天差异有统计学意义(P<0.05),术后第7天差异无统计学意义(P>0.05)。结论 老年患者在全身麻醉手术期间使用Narcotrend监测,有利于精确控制麻醉深度,从而减少麻醉药用量,缩短苏醒时间,而且可以减少术后早期认知功能障碍的发生率。

关键词: Narcotrend, 认知功能障碍, 术后并发症