Abstract: 【Abstract】〓Movement disorder caused by articular injury and synovial diseases is one of difficult clinical problems. Synovium mesenchymal stem cells (SMSCs) are the new member of mesenchymal stem cells family. SMSCs are considered to be promising seeded cells for bone and joint diseases because of showing outstanding proliferation and cartilage differentiation capacity. SMSCs have attracted much attention in recent years. Here,we aim to review the current state of SMSCs research about reviewing isolation and purification,basic characteristics,and clinical application of SMSCs,and discuss the related problems.

Key words: Synovium mesenchymal stem, Immunophenotype, Immunoregulation, Seed cells

摘要： 【摘要】〓软骨损伤及滑膜组织疾病引起的肢体运动障碍是临床治疗的棘手问题之一,滑膜间充质干细胞(SMSCs)是骨髓间充质干细胞(MSCs)家族的新成员,由于其具有突出的增殖特性和强大的成软骨分化能力等优点,SMSCs被视为治疗骨关节系统疾病颇有希望的种子细胞,已成为近年来研究的热点。本文就近年来有关SMSCs的分离纯化、基本特性及临床应用等方面进行综述,旨在阐明SMSCs的研究现状及存在的相关问题。

关键词: 滑膜间充质干细胞, 免疫表型, 免疫调控, 种子细胞