Abstract: 【Abstract】〓Objective〓To investigate a method for predicting sensitively and specifically hepatic insufficiency by comparing globulin/cholinesterase(G/C) ratio with Child-Pugh scores in advance of hepatec-tomy in liver cancer patients. Methods〓We recruited patients retrospectively from May 2012 to January 2014 undergoing HCC hepatectomy in Sun Yat-Sen University Memorial Hospital,.including 138 males and 36 females. The study was conducted by analysis of G/C ratio compared with A,.B and C levels of Child-Pugh classification respectively. Results〓G/C ratio had positive relationship with Child-Pugh classification in evaluating preo-perative liver function(r=0.307, P<0.05). G/C ratio (OR=4.668, P=0.04) preceded Child-Pugh classification (OR=2.909, P=0.126) in predicting incidence of postoperative hepatic insufficiency. Conclusion〓In our present study, G/C ratio had positive correlation with Child-Pugh classification in evaluating liver reserve function preoperatively in HCC patients, but the former was superior to Child-Pugh classification in predicting hepatic insufficiency postoperatively.

Key words: Globulin(G)/cholinesterase(C) ratio, Child-Pugh classification, Liver reserve function, Hepatic insufficiency

摘要： 【摘要】〓目的〓通过对肝癌患者术前血清球蛋白/胆碱脂酶比值与child-pugh评分的对比性分析,探讨肝癌术前更简单、更可靠的反映肝脏储备功能和对术后肝功能不全发生率更具敏感性、特异性的方法。方法〓回顾性分析中山大学孙逸仙纪念医院从2012年5月至2014年1行肝癌切除患者共174例,其中男性138例,女性36例,分析患者术前血清球蛋白/胆碱脂酶比值(G/C),与child-pugh分级中A、B、C三级病例进行对比分析。结果〓球蛋白/胆碱脂酶比值与child-pugh评分在术前肝功能评估中均呈正相关(r=0.307;P<0.05)。血清球蛋白/胆碱脂酶比值(OR=4.668,P=0.04)在预测术后肝功能不全发生机率优于Child-Pugh分级(OR=2.909, P=0.126)。结论〓肝癌患者术前血清球蛋白/胆碱脂酶比值评估术前肝储备功能与child-pugh分级呈正相关,但在预测术后肝功能不全发生机率优于child-pugh分级。

关键词: 球蛋白(G)/胆碱脂酶(C)比值, Child-Pugh分级, 肝储备功能, 肝功能不全