Expression and significance of glutathione peroxidase 1 gene and super oxide dismutase 1 gene in adenoid cystic carcinoma

doi:j.issn.1009-976X.2013.06.020

Abstract

Abstract: 【Abstract】 Objective To detect the expression of Glutathione Peroxidase 1 (GPX1) gene and Super Oxide Dismutase 1 (SOD1) gene in salivary adenoid cystic carcinoma (SACC) and demonstrate their potential correlation and theirs relationships with clinicopathological features and prognoses of SACC. Methods The expression of GPX1 and SOD1 in 35 SACC cases and 18 samples of adjacent salivary gland tissues were detected by immunochemical staining method. The potential correlation between GPX1 and SOD1 and clinicopathological features in SACC were analyzed. SPSS 13.0 software package was used for statistical analysis. Results The expression of GPX1 and SOD1 in the nucleus of SACC were significantly higher than that in adjacent salivary gland tissues (P<0.001). In SACC, the nuclear express of GPX1 and SOD1 were positively related with perineural invasion (Fisher's exact test, P=0.044 and 0.009). And the expression of GPX1 was positively related with the expression of SOD1(P=0.022). Conclusion The nuclear express of GPX1 and SOD1 were significantly correlated with the perineural invasion of SACC. It may serve as valuable markers for diagnosis and an indicator for prognosis of SACC.

Key words: GPX1, SOD1, Salivary gland, Adenoid cystic carcinoma, Immunohistochemistry

摘要： 【摘要】目的研究谷胱甘肽过氧化物酶1(Glutathione Peroxidase, GPX1)基因和超氧化物歧化酶1(Super Oxide Dismutase,SOD1)基因在唾液腺腺样囊性癌(SACC)中的表达,探讨两者在肿瘤中的潜在联系以及它们与SACC的临床病理特征及患者预后的关系。方法采用免疫组化法检测35例SACC和18例癌旁腺体中GPX1和SOD1的蛋白表达,分析GPX1和SOD1的表达是否存在相关性及各自与SACC临床病理特征之间的关系。采用SPSS 13.0软件包对数据进行统计学分析。结果 GPX1和SOD1在SACC肿瘤组织细胞核中的表达显著高于癌旁腺体(P<0.001);肿瘤细胞核中GPX1和SOD1的表达均与神经浸润有关(P=0.044和0.009);且两指标间存在正相关(P=0.022)。结论 GPX1和SOD1的核表达均与腺样囊性癌神经浸润密切相关,对腺样囊性癌诊断和预后评估具有重要参考价值。

关键词: 谷胱甘肽过氧化物, 超氧化物岐化酶, 唾液腺, 腺样囊性癌, 免疫组化

CLC Number:

R739.87

Liu Yeqing, Li Haifeng, Han Jingjing, Huang Zhiquan, Li Haigang. Expression and significance of glutathione peroxidase 1 gene and super oxide dismutase 1 gene in adenoid cystic carcinoma[J]. Lingnan Modern Clinics in Surgery, 2013, 13(06): 537-540.

柳叶青李海凤韩静静黄志权李海刚. GPX1和SOD1在腺样囊性癌中的表达及其意义[J]. 岭南现代临床外科, 2013, 13(06): 537-540.

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