Abstract: Objective To explore the prognostic value of extracellular volume fraction （ECVf） in patients with pancreatic cancer after operation. Methods A total of 66 patients with pancreatic cancer who underwent surgical treatment in Sun Yat-Sen Memorial Hospital of Sun Yat-sen University from January 2014 to December 2022 were selected. The multi-detectorrow CT scanner was used for multi-phase enhanced CT scanning, and the images of the non-contrasted phase and equilibration phase were obtained. The ECVf of pancreatic cancer lesions was calculated by formula. According to the median ECVf, the patients were divided into high ECVf group and low ECVf group. The prognosis of the two groups was analyzed, and a nomogram model was established to predict the prognosis of patients with pancreatic cancer treated after operation. Results The high ECVf group had longer OS （P=0.002） and DFS （P=0.024） than the low ECVf group. The median OS of high ECVf group and low ECVf group were 32.0 months and 20.3 months respectively, and the median DFS were 20.7 months and 12.3 months, respectively. The area under curve （AUC） of nomogram model for predicting 1-year, 2-year and 3-year survival rates were 0.854, 0.802 and 0.707, respectively. Conclusion ECVf can be used as a prognostic indicator for patients with pancreatic cancer after operation.

Key words: pancreatic ductal adenocarcinoma, extracellular volume fraction, computed tomogram, prognosis

摘要： 目的 探索细胞外体积分数（ECVf）对胰腺癌术后患者预后的预测价值。方法 选取2014年1月至2022年12月中山大学孙逸仙纪念医院因胰腺癌行手术治疗的66例患者。使用多层探测器CT扫描仪行多期增强CT扫描,获取平扫期与平衡期图像,通过公式计算胰腺癌病灶ECVf。根据ECVf中位数将患者分为高ECVf和低ECVf两组,分析两组患者预后是否存在差异,并联合临床病理特征建立列线图模型以预测胰腺癌术后患者预后。结果 高ECVf组较低ECVf组具有更长的OS（P=0.002）和DFS（P=0.024）。高ECVf组和低ECVf组的中位OS分别为32.0个月和20.3个月,中位DFS分别为20.7个月和12.3个月。列线图模型预测患者1年、2年、3年生存率的曲线下面积（AUC）分别等于0.854、0.802、0.707。结论 ECVf可以作为胰腺癌术后患者的预后预测指标。

关键词: 胰腺导管腺癌, 细胞外体积分数, 电子计算机断层扫描, 预后