Research progress on the changes of intestinal flora in acute pancreatitis by Euphorbia kansui

doi:10.3969/j.issn.1009-976X.2023.05.014

Abstract

Abstract: Acute pancreatitis, casuing systemic inflammatory response, can lead to intestinal flora disturbance, gut barrier dysfunction and intestinal immune function impairment. The underlying pathogenesis is closely associated with gut microorganisms, which significantly increases the mortality of sever acute pancreatitis （SAP）. Recently the imbalance of intestinal flora is being regarded as an critical potential therapeutic target of AP via traditional Chinese medicine, in with Euphorbia kansui has played a important role in the treatment of SAP. This review aims to provide more basic research and clinical application evidence of Kansui in the cure of AP from the perspective of gut microorganisms, through summarizing and analyzing the existed pertinent literature.

Key words: acute pancreatitis, Euphorbia kansui, intestinal flora

摘要： 急性胰腺炎（AP）诱发的全身炎症反应可导致肠道菌群紊乱、肠道屏障功能和肠道免疫功能受损。Ap发病机制与肠道微生物密切相关,并与重症急性胰腺炎（SAP）的高病死率相关。近年来,肠道菌群失调被认为是当前中医药治疗AP的重要潜在靶点,其中中药甘遂在治疗SAP中发挥了重要功效。本文结合最新研究成果,从肠道菌群的角度对中药甘遂治疗AP的有关作用机制进行综述,以期为中药甘遂治疗AP提供更多的基础研究参考和临床参考。

关键词: 急性胰腺炎, 甘遂, 肠道菌群

CLC Number:

R657.5

YU Zhi-min, SHEN Zhan-tao, ZHONG Xiao-sheng. Research progress on the changes of intestinal flora in acute pancreatitis by Euphorbia kansui[J]. Lingnan Modern Clinics In Surgery, 2023, 23(05): 444-448.

喻志敏, 沈展涛, 钟小生. 中药甘遂在急性胰腺炎肠道菌群中的研究进展[J]. 岭南现代临床外科, 2023, 23(05): 444-448.

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