Abstract: Objective To evaluate the usefulness and efficient of the surgical excision combined with Fluorouracil（5-FU） Implants in breast cancer patients with local regional relapse （LRR） by comparing with non-surgical. Methods Totally 726 patients treated as breast cancer from January 2010 to December 2019 in Jiangmen Central Hospital were registered, in which 27 patients with LRR were enrolled. Analysis of the general data and prognosis information of two groups, surgical excision with Fluorouracil Implants and non-surgical. Results The treatment decision has no significant correlation with the relapse age, LRR pattern and result of IHC （P>0.05）. Patients accepted surgical excision with Fluorouracil Implants has the reducing risk of secondary LRR significantly, with a median LRPFS is 28 months, while the median LRPFS of patients without surgery is 16 months （χ²=6.38,P=0.012）. Whether accepting the surgical treatment did not improve overall prognosis, and there was no statistically significant difference OS in both groups （P>0.05）. Conclusion For breast cancer patients with LRR, accepted positive surgical excision of the lesions and combined with 5-FU implants, then supplemented by consolidating radiation therapy, which can effectively reinforce the effect of local lesion control, extend the local progression-free survival and improve the quality of life.

Key words: breast cancer, local regional relapse, surgical excision, fluorouracil implants

摘要： 目的 初步分析手术切除联合植入缓释型氟尿嘧啶（5-FU）与非手术治疗对局部区域复发的乳腺癌患者的效果,探讨前者的临床作用及应用前景。方法 回顾性入组自2010年01月至2019年12月于江门市中心医院甲乳外科就诊并进行治疗的乳腺癌患者共726例,筛选符合入组条件的局部区域复发（LRR）患者共27例,其中13例选择手术切除联合植入型5-FU,14例非手术治疗,所有患者均接受巩固放疗。比较两组患者的一般资料及预后信息。结果 治疗方法的选择与复发年龄,LRR类型、IHC结果等无明显相关（P>0.05）。接受手术治疗联合植入型5-FU的患者较非手术治疗患者显著降低二次局部区域复发风险,其中位LRPFS为28个月,优于非手术组的16个月（χ²=6.38,P=0.012）。是否接受手术治疗并未改善整体预后,两组患者OS差异无统计学意义（P>0.05）。结论 针对乳腺癌术后LRR患者,接受积极手术切除病灶同时植入缓释型5-FU,辅以巩固放疗,可有效提高局部病灶控制效果,延长局部无进展生存期,改善生活质量。

关键词: 乳腺癌, 局部区域复发, 手术治疗, 缓释型5-FU