Abstract: ［Abstract］ Objective To evaluate the accuracy and safety of the Clinical application of Mammotome Biopsy system and wire localization in nonpalpable breast lesions （NPBL）. Methods Eighty?four patients with NPBL were randomized into Mammotome Biopsy system group （MMT） and wire localization group （WL） and the diagnosis results， time， bleeding， specimen size， cost and complication were compared between two groups. Results Biopsy was successful in both groups. Compared with WL group， MMT group had shorter operation time， less blood loss and smaller specimen volume， and the difference was statistically significant （P<0.05）. In terms of hospital cost and complication rate， MMT group was significantly higher than WL group （P<0.05）. The diagnostic accordance rate of MMT was 97.6% （41/42）. Compared with WL group （42/42）， there was no significant difference （P>0.05）. In MMT group the positive rate of the incisional margin was higher than WL group. Conclusion For biopsy of NPBL， the Mammotome Biopsy system and the wire localization biopsy have high diagnostic accuracy. In MMT group， it takes less time to perform， has fewer mammary tissue specimen to be removed， has a smaller incision and better cosmetic effect， but it is more expensive and has a higher incidence of complications than the WL group. The positive rate of the incisional margin was higher after the Mammotome Biopsy system. For the diagnosis and treatment of high?risk patients， the choice of wire localization biopsy is more appropriate.

Key words: breast neoplasms, wire localization biopsy, nonpalpable breast lesions, Mammotome Biopsy system

摘要： ［摘要］ 目的 评价麦默通旋切活检和金属导丝定位活检对临床触诊阴性乳腺病灶（NPBL）诊断的准确性和安全性。方法 将84例NPBL患者采用随机数字表法随机分为两组，分别行麦默通旋切活检（MMT组，42例）和金属导丝定位活检（WL组，42例），比较两组的诊断结果、手术指标、费用和并发症等。结果 两组患者均成功活检。MMT组患者手术用时短、出血量少、标本体积小，与WL组比较差异有统计学意义（P<0.05）。在费用和并发症发生率方面，MMT组显著高于WL组（P<0.05）。MMT组冰冻切片确诊41例（97.6%），未确诊1例；WL组冰冻切片确诊42例，两组的差异无统计学意义（P>0.05）。对活检后的切缘进行评价，MMT组5例行根治性手术的患者中，有1例切缘阳性，而WL组6例患者中，未见切缘阳性。结论 对于NPBL的活检，麦默通旋切活检和金属导丝定位活检均有很高的诊断准确性。麦默通旋切活检手术耗时短，切除乳腺组织标本量少，手术切口小，美容效果好，但其费用高，并发症发生率较金属导丝定位活检高。麦默通旋切活检后可能有较高的切缘阳性率，对于临床上考虑为高危的病灶，建议选择金属导丝定位活检较为合适。

关键词: 乳腺肿瘤, 麦默通旋切活检, 金属导丝定位活检, 临床触诊阴性