Abstract: ［Abstract］ Objective To evaluate the efficacy of urokinase intrathoracic perfusion therapy for early coagulated hemothorax after pleural dissection surgery. Methods Sixty?three patients with coagulated hemothorax after pleural exfoliation from March 2014 to December 2016 underwent urokinase intrathoracic perfusion. The thoracic drainage， X?ray examination results were recorded and comprehensively analyzed therapeutic effect. Results The perfusion process was smooth in all 63 patients， in which 48 cases were cured， 13 cases were effective and 2 cases were ineffective. The cure rate was 84.1% and the total effective rate was 96.8%. The patients were well tolerated during the whole treatment. Three cases had low fever， 8 had mild chest pain， 7 had shortness of breath and one case had massive hemorrhage， without other serious adverse reactions. Conclusion Treatment of early coagulated hemothorax with intrapleural perfusion of urokinase is a simple， safe， minimally invasive procedure， with definite efficacy， low incidence of adverse reactions.

Key words: urokinase, coagulated hemothorax, pleural decortications

摘要： ［摘要］ 目的 探讨采用尿激酶胸腔灌注的方法治疗胸膜剥脱术后凝固性血胸的疗效。方法 选取2014年3月至2016年12月我院胸外科胸膜剥脱术后并发凝固性血胸的63例患者，均采用尿激酶胸腔灌注方法进行治疗，报告引流液情况及X线检查结果，综合分析其治疗效果。结果 所有人注药过程顺利，其中48例治愈，13例有效，2例无效。治愈率84.1%，总有效率96.8%，整个治疗过程中患者均耐受良好，8例伴有轻度胸痛、7例气促、3例出现低热，经对症治疗后缓解，仅1例出现大出血，经药物止血治疗后治愈，无其他严重不良反应。结论 尿激酶胸膜腔内灌注治疗早期凝固性血胸简单、安全、创伤小、疗效肯定，不良反应发生率低，无须特殊设备。

关键词: 凝固性血胸, 胸膜纤维板剥脱, 尿激酶