Abstract: Objective To investigate the clinicopathological features and diagnosis of myxoifibroma of jaw bone. Methods We collected 7 cases of maxillary myxoifibroma from July 2018 to March 2022 in the Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. The clinical data, imaging, morphology, immunohistochemical results and treatments of the patients were analyzed. Results There were 3 males and 4 females in 7 cases of maxillary myxoifibroma, aged from 5 to 50 years old, with a median age of 36 years and an average age of 29.286±18.382 years. All patients underwent surgical treatment. Both imaging and microscopy showed bone destruction. The tumor showed a loose mesh structure, matrix myxedema. Spindle or star-axed tumor cells were few and scattered, with oval nuclei and rare nuclear mitosis. Vimentin was consistently expressed in tumor cells （4/4） and Actin was expressed in some cases （2/5）, while Desmin, S-100, CD34 and β-catenin were totally negative. Ki67 positive index was 2% ~ 5%. Conclusion Maxillary myxoifibroma is a rare and benign otogenic tumor, but it is locally invasive and has a high recurrence rate, requiring follow-up. Preoperative imaging is tend to be confused with other jaw tumors, and histopathological and immunohistochemical inspections are required to confirm the diagnosis. Surgical excision is the main treatment method at present.

Key words: odontogenic tumor, odontogenic myxofibroma, odontogenic myxoma, diagnosis

摘要： 目的 探讨颌骨粘液纤维瘤的临床病理特征及诊断要点。方法 我们收集了中山大学孙逸仙纪念医院病理科2018年7月到2022年3月期间手术送检的7例颌骨粘液纤维瘤病例,分析患者临床资料、影像检查、形态学、免疫组化结果及治疗方案。结果 7例颌骨粘液纤维瘤患者中男性3例,女性4例,年龄5~50岁,中位年龄36岁,平均年龄29.286±18.382岁。所有患者均行手术治疗。影像学及镜下均见骨质破坏,肿瘤呈疏松细丝网状结构,基质粘液水肿样,肿瘤细胞少而散在分布,细胞梭形或星芒状,核卵圆形,核分裂象罕见。肿瘤细胞一致性表达Vimentin（4/4）,部分病例表达Actin（2/5）,Desmin、S-100、CD34、β-catenin均阴性,Ki67阳性指数2%~5%。结论 颌骨粘液纤维瘤是罕见的良性牙源性肿瘤,但有局部侵袭性,有较高复发率,需要随诊。术前影像学容易和其他颌骨的肿瘤混淆,诊断需要组织病理和免疫组织化学来确诊。手术切除是目前主要的治疗方案。

关键词: 牙源性肿瘤, 牙源性粘液纤维瘤, 牙源性粘液瘤, 诊断