Abstract: Objective To explore the correlation of ESM-1 expression at the immunohistochemical level and the recurrence of pituitary adenoma. Methods Immunohistochemical staining of ESM-1 antibody was performed on 33 pituitary adenoma patients attending our hospital from February 2018 to April 2021. Results The relapse group had higher ESM-1 expression （P=0.004）, while age, sex and tumor maximum diameter had no significant correlation with ESM-1 expression, no significant difference in ESM-1 expression before and after relapse, and no obvious correlation between ki-67-positive protein expression index and ESM-1 expression. Conclusions The expression of ESM-1 is clearly correlated with tumor recurrence, and it guides the treatment and prognosis of pituitary adenoma.

Key words: pituitary adenoma, immunohistochemistry, ESM-1

摘要： 目的 探讨ESM-1在免疫组化水平的表达与垂体腺瘤复发的相关性。方法 对2018年2月至2021年4月就诊于我院的33例垂体腺瘤患者进行ESM-1抗体的免疫组化染色并进行分析研究。结果 复发组相较首发组有更高的ESM-1表达（P=0.004）,而年龄、性别及肿瘤最大径均与ESM-1表达无明显相关性,患者复发前后的ESM-1表达无明显差异,ki-67蛋白阳性表达指数与ESM-1表达之间无明显相关性。结论 ESM-1的表达与肿瘤复发有明显相关性,对于垂体腺瘤的治疗及预后有指导作用。

关键词: 垂体腺瘤, 免疫组化, ESM-1