A systematic review of the mechanisms of osteoarthritis and metabolic syndrome

doi:10.3969/j.issn.1009-976X.2021.06.019

Abstract

Abstract: Both osteoarthritis and metabolic syndrome are systemic diseases, which are closely related to global oxidative stress, inflammatory response, vascular endothelial damage, genetic genes, hormone secretion, metabolic abnormalities, obesity, biomechanical changes, hypertension and lipid metabolism abnormalities. Osteoarthritis and metabolic syndrome are interrelated and promote each other in pathogenesis. Actively controlling of metabolic syndrome,the progression of osteoarthritis can be alleviated. Improving osteoarthritis activity limitations, metabolic syndrome maybe improved. Because of the holistic concept, another thinking model for clinical diagnosis and treatment of osteoarthritis is provided.

Key words: osteoarthritis, metabolic syndrome, pathogenesis, review

摘要： 骨关节炎与代谢综合征均属于全身系统性疾病,二者在发病机制上相互关联,相互促进,与整体氧化应激、炎症反应、血管内皮损伤、遗传基因、激素分泌、代谢异常、肥胖、生物力学改变、高血压及脂质代谢异常等密切相关。积极控制代谢综合征有助于延缓骨关节炎发病进展,改善骨关节炎活动受限有助于减轻代谢综合征,整体观念为临床骨关节炎的诊断及治疗提供又一种思维模式。

关键词: 骨关节炎, 代谢综合征, 发病机制, 综述

CLC Number:

R681.5

LI Bo. A systematic review of the mechanisms of osteoarthritis and metabolic syndrome[J]. Lingnan Modern Clinics In Surgery, 2021, 21(06): 679-683.

李波. 骨关节炎与代谢综合征相关机制的系统综述[J]. 岭南现代临床外科, 2021, 21(06): 679-683.

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