Abstract: ［Abstract］ Objective To systematically evaluate the effects of antiseptic barrier cap use and manual disinfection on the incidence of CLABSIs. Methods The studies included were retrieved from Embase， Medline Ovid， Web?of?science， EBSCO， Cochrane Library， PubMed， CBM， CNKI， WANGFANG and VIP database until March 2， 2018. Two reviewers independently assessed the studies and extracted data. The primary outcome， reduction in CLABSIs per 1000 catheter?days， expressed as an incidence rate ratio （IRR）， was analyzed by RevMan 5.3. Results A total of 302 articles were identified as potentially relevant and after exclusion of duplicates， 176 articles were screened based on title and abstract|20 articles were read full text. Eventually， 11 studies were included in the systematic review， and nine of these 11 in the random effects meta? analysis. The pooled IRR showed that use of the antiseptic barrier cap was effective in reducing CLABSIs （IRR=0.60， 95%CI=0.52-0.70， P<0.0001）. Conclusion Use of an antiseptic barrier cap is associated with a lower incidence CLABSIs and is an intervention worth adding to central?line maintenance bundles.

Key words: Central line?associated bloodstream infections, Antiseptic barrier cap, Manual disinfection

摘要： ［摘要］ 目的 系统评价消毒帽和常规手动消毒对CLABSIs发病率的影响。方法 作者在2018年3月2日前系统地搜索了Embase，Medline Ovid，Web of Science，EBSCO，Cochrane图书馆，PubMed Publisher，中国生物医学文献光盘数据库（CBM），中国期刊全文数据库（CNKI），万方数据库，维普全文电子期刊（VIP）等数据库。按照纳入排除标准由两人独立进行文献筛选和数据提取，并进行文献质量评价，以每1000导管天CLABSI减少为主要观察指标，表示为发病率比率（IRR），采用RevMan 5.3统计软件进行分析。结果 总共302篇文章被认定为潜在相关文章，排除重复文章后，根据标题和摘要对953篇文章进行筛选；20篇文章全文阅读。最终，11项研究纳入了系统评价，其中9项纳入了荟萃分析。合并的IRR显示使用消毒帽可有效减少CLABSI（IRR = 0.60，95%CI = 0.52~0.70，P<0.0001）。结论 使用消毒帽与CLABSI发生率较低有关，并且是值得添加到中心血管导管的干预措施。

关键词: 常规手动消毒, 中心静脉导管相关性血流感染, 消毒帽