Abstract: ［Abstract］ Objective To investigate the sedative and analgesic effect and safety of dexmedetomidine in painless gastroscopy. Methods Sixty patients who underwent painless gastroscopy were enrolled in the observation group and the control group. The former was pumped with dexmedetomidine 0.1 mg/kg and the latter with propofol 1.5 mg/kg. The vital signs，sleep，intraoperative operation，waking time and Ramsay score were used to observe and record the sedative and analgesic effects in two groups of patients during gastroscopy. Results The sleep，operation time and awaking time in observation group were shorter than that in control group. The Ramsay score of the observation group was higher than that of the control group（P<0.05）. The differences of vital signs between two groups were not statistically important（P>0.05）. Conclusion Dexmedetomidines in painless gastroscopy is a reliable and safe in sedation andanalgesia，and the vital signs are stable. With special care，the examination can be completed smoothly.

摘要： ［摘要］ 目的 探讨右美托咪定在无痛胃镜检查中的镇静镇痛效果和安全性。方法 选取 60例进行无痛胃镜检查的病人，分为两组，即右美托咪定组和丙泊酚组，前者微泵泵入右美托咪定0.1 mg/kg，后者静脉注射丙泊酚 1.5 mg/kg。观察记录两组病人胃镜检查全程中的生命体征、入眠、检查、自醒时间、Ramsay 评分、不良反应发生率。结果 右美托咪定组的入眠、检查、自醒时间均短于丙泊酚组，右美托咪定组Ramsay 评分高于丙泊酚组（P<0.05），两组生命体征变化、不良反应发生率差异不明显（P>0.05）。结论 无痛胃镜检查中应用右美托咪定，其镇静镇痛可靠、安全，生命体征平稳，配合专门护理，可顺利完成检查。

关键词: 镇静, 临床护理, 右美托咪定, 无痛胃镜