Abstract: ［Abstract］ Objective To investigate the expression of Cyclophillin B （PPIB） protein in Thyroid papillary carcinoma（PTC）and their correlation with clinicopathological factors and prognosis. Methods Tissue samples from 98 cases of PTC and 58 cases adjacent normal tissues were surgically resected at the Sun Yat?Sen Memorial Hospital of Sun Yat?sen University from 2011 to 2014. The expression of PPIB protein were carried out by immunohistochemistry, the correlation of PPIB protein and clinicopathological features and prognosis were statistical analyzed. Results PPIB protein expression was significantly higher than normal thyroid tissue, PPIB tended to significantly correlated with age （P=0.025）, lymph node metastasis（P=0.046）, Capsular invasion （P=0.034） and TNM stage （P=0.036）. The Kaplan?Meier survival analysis suggested that PPIB overexpression was significantly associated with lymph node recurrence?free survival （LN?RFS）. Multivariate analysis confirmed the PPIB expression was an independent prognostic factor for LN?RFS in PTC patients. Conclusion In conclusion, high PPIB expression correlates with poor survival in PTC patients, which is expected to become an important indicator for clinical treatment and prognosis.

Key words: clinicopathological features, prognosis, thyroid papillary carcinoma, immunohistochemistry, PPIB

摘要： ［摘要］目的 探讨甲状腺乳头状癌（PTC）中亲环素B（CyclophillinB，PPIB）蛋白表达及其与临床病理因素以及预后的关系。方法 收集2011年至2014年在中山大学孙逸仙纪念医院行PTC切除的患者98例及58例癌旁组织石蜡标本。采用免疫组织化学实验检测组织中PPIB的表达水平，并统计分析PPIB蛋白表达与临床病理特征及预后的相关性。结果 PPIB的表达水平明显高于正常甲状腺组织，PPIB的高表达与年龄（P＝0.025）、淋巴结转移（P＝0.046）、包膜侵犯（P＝0.034）和TNM分期（P＝0.036）密切相关，Kaplan?Meier生存分析表明PPIB高表达与淋巴结无复发生存率（LN?RFS）显著相关，多因素分析证明PPIB表达是PTC病人LN?RFS的独立危险因素。结论 PPIB高表达与PTC患者预后较差相关，PPIB有望成为PTC临床治疗以及预后评估的重要指标。

关键词: 免疫组织化学, PPIB, 甲状腺乳头状癌, 临床病理特征, 预后