Abstract:

 Objective To investigate the changes of cytokines and immune function in patients with recurrent condyloma acuminatum. Methods A total of 87 patients with condyloma acuminatum were included in this study, and were assigned to two groups, primary group（n=48）, recurrent groups （n=39）. Another 42 healthy subjects were selected as controls （control group）. The peripheral blood levels of CD4+ T?lymphocyte, CD8+ T?lymphocyte, CD4+/CD8+ ratio and the levels of IL-2, IL?4, IL?6 were detected and analyzed statistically. Results There were significant differences in the levels of IL ?2, IL?4, IL?6, CD4+ T?lymphocyte, CD8+?T lymphocyte, CD4+/CD8+ ratio between the three groups（all P values were less than 0.05）. Serum IL?2, IL?6, CD4+/CD8+ ratio in the patients with relapse were sig-nificantly lower than those in the control group（all P values were less than 0.05）. There was no signifi-cant difference in serum IL?2, IL?4, IL?6, CD4+, CD8+, CD4+/CD8+ levels between the initial group and the control group（all P values were more than 0.05）. Conclusion In patients with recurrent condylo-ma acuminatum, there is an imbalance of cellular immune function, and this cellular immune dysfunc-tion may be a cause of recurrent attacks

Key words: cytokines, cellular immunity, human papillomavirus, T cell subsets, condyloma acuminata

摘要：

目的 探讨尖锐湿疣复发患者的细胞因子及免疫功能的变化规律。方法 选取我院皮肤科收治的87例尖锐湿疣患者。将患者分为初发组与复发组。初发组48例, 复发组39例，选取同期体检的42名健康者作为对照组。对3组人员的血清细胞因子IL?2、IL?4、IL?6及外周血T淋巴细胞亚群CD4+、CD8+、CD4+/CD8+分布水平进行检测及统计分析。结果 3组患者的IL?2、IL?4、IL?6、CD4+细胞、CD8+细胞、CD4+/CD8+水平之间比较差异均具有显著性（P<0.05）。两两比较后发现，复发组患者的血清IL?2、IL?6、CD4+细胞、CD4+/CD8+水平均显著低于初发组与对照组（P<0.05），血清IL?4、CD8+细胞水平均显著高于初发组与对照组（P<0.05）；初发组患者的血清IL?2、IL?4、IL?6、CD4+细胞、CD8+细胞、CD4+/CD8+水平与对照组比较差异均无显著性（P>0.05）。结论 尖锐湿疣复发患者存细胞免疫功能的失衡，细胞免疫功能低下可能是导致其反复发作的一个原因。

关键词: T 细胞亚群 , 人类乳头瘤病毒, 尖锐湿疣, 细胞因子, 细胞免疫