Abstract: 【Abstract】 Occult pancreaticobiliary reflux（OPR/OPBR）is defined as pancreaticobiliary reflux （PBR）occurs in individuals with a normal pancreaticobiliary junction （NPBJ）. Studies have shown that many diseases of biliary system, especially gallbladder cancer, are closely associated with OPR. However, these cases present no clinical symptoms and is also impossible to accurately detected by using conventional imaging examinations. Understanding and further research of OPR have great importance of significance for clinical guiding. In this article, we review the progress in research of OPR.

Key words: Bile amylase, Sphincter of oddi, Occult pancreaticobiliary reflux, Common channel, Biliary tract diseases

摘要： 【摘要】隐匿性胰胆返流（OPR/OPBR）是指胰胆返流（PBR）发生在胰胆合流正常（NPBJ）患者中的一种病理过程。研究发现OPR与诸多胆道系统疾病，特别是胆囊癌关系密切。然而，OPR患者早期无明显临床表现，常规的影像学检查也难以发现，对OPR的了解及进一步研究对临床有重要的指导意义。本文就OPR目前的研究进展作一综述。

关键词: oddi括约肌, 隐匿性胰胆返流, 共同通道, 胆道疾病, 胆汁淀粉酶