Abstract: 【Abstract】 Objective To summarize the surgical experience of sentinel lymph node biopsy in early staged breast cancer. Methods Retrospectively analyzed the clinical data of 78 patients with early stage breast cancer undergone sentinel lymph node biopsy in our hospital from January 2013 to December 2015. Results A total of 78 patients suffering from breast cancer were enrolled. Mean age was 54 years （range 32-75）. Of 78 cases, the lesion was localized on the right breast in 48（62%）, while was localized on the left breast in 30（38%）. Also, the tumor involved the upper-outer quadrant in 46（59%）patients, the lower external quadrant in 13（17%）, the upper-inner quadrant in 11（14%）and the inferior-internal quadrant in the remaining 8（10%）. All removed breast lesions were histologically malignant: 55（70%） patients diagnosed as infitrating ductal carcinoma（IDC）, 16（21%）ductal carcinoma in situ（DCIS）, 5（6%） infiltrating lobular carcinoma（ILC）and 2（3%）as mixed invasive cancer. The successful rate of SLNB is 90%（70）, in which pathological positive rate of SLNB was 34%（24）, while pathological negative rate of SLNB was 66%（46）. Medium follow-up was 12 months, and only one case developed axillary recurrence. Conclusion Sentinel lymph node biopsy is a safe and effective way to evaluate the status of axillary and the good results are obtained when undertaken by an experienced surgeon.

Key words: Sentinel lymph node biopsy, Axillary surgery, Early stage breast cancer

摘要： 【摘要】目的总结早期乳腺癌前哨淋巴结活检的手术经验。方法回顾性分析2012年1月至2016年6月在我院乳腺外科行乳腺癌腋窝前哨淋巴结活检手术的78例早期乳腺癌病人的临床资料。结果中位年龄54岁（范围32~75岁），其中48例（62%）患者为右乳癌，30例（38%）为左乳癌。同时，46例（59%）患者肿物位于外上象限，13例（17%）肿物位于外下象限，11例（14%）位于内上象限，8例（10%）位于内下象限。55例（70%）患者为浸润性导管癌（IDC），16例（21%）为导管原位癌（DCIS），5例（6%）为浸润性小叶癌（ILC），2例（3%）为其他类型浸润性癌。前哨淋巴结检出率为90%（70/78），其中前哨淋巴结阳性率为34%（24/70），前哨淋巴结阴性率为66%（46/70）。前哨淋巴结准确率为93%（65/70），假阴性率为11%（5/46）。中位随访时间为12个月，腋窝淋巴结复发1例，余均未见复发事件。结论当前结果符合文献报道，早期乳腺癌腋窝淋巴结活检是一种安全的肿瘤腋窝淋巴结状态评估手段，但需要一定经验的外科医生实施。

关键词: 腋窝手术, 前哨淋巴结活检, 早期乳腺癌