Abstract: 【Abstract】〓Objective〓To investigate clinicopathological characteristics of young breast cancer and its effect on clinical prognosis. Methods〓In this study, 85 cases of young breast cancer (≤35 years) in our hospital were treated as the youth group, 98 cases (>35 years) in the same period were recruited as the older group. The data, including clinicopathological characteristics, estrogen receptor (ER) and progesterone receptor (PR), Her-2 expression, P53 expression aspect, axillary lymph node metastasis and postoperative 5-year disease-free survival,were analyzed. Results〓There was no significant difference on pathological type, histological grade and clinical stage between the young and the older group (all P values >0.05). There was a significant difference on terms of estrogen receptor (ER), progesterone receptor (PR), Her-2 expression and axillary lymph node metastasis (all P values<0.05), except for P53 expression (P>0.05). The differences of postoperative 5-year disease-free survival in the two groups was statistically significant. Conclusion〓Young breast cancer has characteristics of more aggressive,earlier lymph node metastasis and lower postoperative 5-year disease-free survival compared to the older group, indicating that the early detection and standardized treatment is the best way to improve the prognosis.

Key words: Clinicopathological characteristics, Prognosis, Young breast cancer

摘要： 【摘要】 目的 回顾性研究85例青年乳腺癌的临床病理特点,探讨青年乳腺癌的临床病理特点,并分析其对临床预后的影响。方法〓本研究将收治的青年乳腺癌(≦35岁)85例作为青年组,将同时期收治的中老年乳腺癌(﹥35岁)98例作为中老年组,收集其临床病理类型,包括雌激素受体(ER)和孕激素受体(PR)、Her-2表达、P53表达方面、腋窝淋巴结转移情况和术后5年无病生存率等方面开展比较,进行统计学分析。结果〓青年组乳腺癌和中老年组乳腺癌在病理类型上、组织学分级及临床分期上均无显著差异(P>0.05);在ER、PR及Her-2的表达方面具有显著差异(P<0.05);而在P53的表达方面无显著差异(P>0.05);在腋窝淋巴结转移率方面具有显著差异(P<0.05);两组在术后5年无病生存率上的差异具有统计学意义(P<0.05)。结论〓青年乳腺癌的病理类型提示其较中老年乳腺癌有更强的侵袭性,淋巴结转移较早,5年无病生存率较低,所以在临床上改善其预后最好的办法是早期发现并早期接受规范化治疗。

关键词: 临床病理特点, 青年乳腺癌, 临床预后