Abstract: 【Abstract】 Objective〓To investigate the clinical application of methylene blue staining with different volume in the sentinel lymph node biopsy of one-stage breast cancer. Methods〓From January 2010 to June 2015, 76 patients with one-stage breast cancer were divided into low dose group (0.2 ml), medium dose group (2 ml) and high dose group (4 ml). 1% methylene blue was injected as tracer, and sentinel lymph node biopsy was done. Results〓Among 76 cases, 75 cases were detected sentinel lymph node biopsy. The detection rate was 98.7%, the accuracy rate was 100% and false negative rate was 0. There were significant differences in the incidence of complications in the low dose group and the other two groups. Conclusion〓As a tracer, low dose of 1% methyleneblu showed higher accuracy and less complications in detecting sentinel lymph nodes in one-stage breast cancer patients.

Key words: Methylene blue, Sentinel lymph node, Breast cancer

摘要： 【摘要】〓目的〓探讨不同体积的亚甲蓝注射液染色示踪法在I期乳腺癌前哨淋巴结活检中的临床应用价值。方法〓回顾性分析自2010年1月至2015年6月,76例I期乳腺癌病人,分低剂量组(0.2 mL),中剂量组(2 mL),高剂量组(4 mL)3组,使用1%亚甲蓝注射液为示踪剂,行术中前哨淋巴结活检术。结果〓76例患者,成功施行75例前哨淋巴结活检术,检出率为98.7%,准确率为100%,阴性率为0。低剂量组并发症的发生率与另两组存在差异,其差异具有统计学意义。结论〓低剂量0.2 mL亚甲蓝示踪法在I期乳腺癌前哨淋巴结中,准确性高,并发症少。

关键词: 亚甲蓝, 前哨淋巴结, 乳腺癌