Abstract: 【Abstract】〓Objective〓To investigate the association of MYL9 expression with tumor progression and prognosis in patients with prostate cancer (PCa). Methods〓MYL9 protein expressions in human PCa and non-cancerous prostate tissues were detected by immunohistochemistry analyses. Then,the associations of MYL9 expression with clinicopathological features and clinical outcome of PCa patients were statistically analyzed. Results〓Immunohistochemistry analyses showed that MYL9 expression significantly decreased in PCa tissues as compared with those in non-cancerous prostate tissues. In addition, MYL9 was mainly expressed in the cytoplasm of stromal cells of prostate tissues, and the decreased expression of MYL9 in PCa tissues was significantly correlated with the higher Gleason score. Conclusion〓Our data strongly confirmed for the first time that the decreased expression of MYL9 may play an important role in tumor progression of PCa.

Key words: Myosin light chain, Prostate cancer, Tumor stromal cells

摘要： 【摘要】〓目的〓研究MYL9在前列腺癌组织中的表达水平与前列腺癌临床预后的相关性。方法〓采用免疫组织化学检测80例前列腺癌根治术患者前列腺癌及61例癌旁良性前列腺组织中的MYL9的表达水平,并与前列腺癌(PCa)患者的临床特征相比较。结果〓在良性和前列腺癌组织中,MYL9均主要在前列腺间质而不是在前列腺上皮细胞表达,前列腺癌样本中的MYL9表达水平相对于良性前列腺组织显著下调(PCa=3.21±1.46 vs. Benign=4.63±0.97,P<0.001)并伴有肿瘤间质容积的明显减少。MYL9的下调表达与前列腺癌的Gleason评分(P<0.001)明显相关。结论〓表明MYL9表达下调越明显,则前列腺癌患者临床预后越差。该研究为MYL9在前列腺癌组织中的下调表达可作为预测人类前列腺癌患者的不良临床预后的指标提供了证据。

关键词: 肌球蛋白轻链(MYL9), 前列腺癌, 肿瘤间质