Abstract: 【Abstract】 Objective To investigate the clinicopathological characteristics and prognosis of young patients with gastric carcinoma . Methods Retrospective analysis were conducted on 56 young patients with gastric carcinoma(age≤40 years)who were initial treated in our hospital from Jan.2005 to Dec.2010 in our hospital, and 56 cases had been chosen randomly from the old ones (age≥60 years))over the same period as the control group. Statistical analysis was performed by SPSS13.0 software package. Results In 56 gastric cancer patients of the young group ,the proportion of women was higher than men (χ2= 11.593, P = 0.001). In the young group, Gastric carcinoma more often arised in gastric antrum. The gastric cancer in the young group was mainly poor differentiated adenocarcinoma and anaplastic carcinoma; its proportion was higher than the control group (χ2=16.586, P < 0.001).The clinical stages of most young patients were Ⅲ and Ⅳ.The median survival time after resection was 39.56 months in the young group, and the total of 1，3，5-year survival rates were 80.0%, 52.0%, 24.0% respectively. In the young group the survival rate of patients who had got radical resection was higher than the patients who had undergone palliative surgery (χ2==5.836, P = 0.016).In this study , surgical methods , tumor size, pathological type, clinical stage were main factors affecting the prognosis of young patients with gastric carcinoma (P < 0.05). Conclusion Gastric cancer in the young patients is common in female. Its symptoms are always hidden and it is highly malignant, most cases are diagnosed in later period, early diagnosis and early radical resection is helpful to improve the prognosis of gastric cancer.

Key words: Young patients, Gastric cancer, Clinicpathological, Survival analysis.

摘要： 【摘要】 目的 探讨青年人胃癌的临床病理特点及预后。方法 回顾性分析2005年1月至2010年12月初治的56例青年人胃癌（年龄≤40岁）的临床资料，并随机选取同期56例老年人胃癌（年龄≥60岁）作对照。采用SPSS13.0统计软件分析青年人胃癌的临床病理特点及与预后的关系。结果 56例青年人胃癌女性比例高于男性（χ2 =11.593，P=0.001）；肿瘤多位于胃窦部；病理类型以低分化腺癌和未分化癌为主，高于对照组（χ2 =16.586，P＜0.001）；临床分期以中晚期多见；术后生存中位时间为39.56个月，1、3、5 年生存率分别为80.0%、52.0%、24.0%；行根治性手术患者生存率高于姑息性手术患者（χ2 =5.836，P=0.016）；手术方式、肿瘤大小、病理类型、临床分期是影响青年人胃癌预后的主要因素(P＜0.05)。结论 青年人胃癌以女性居多，起病隐匿，确诊多为中晚期，恶性程度高，应重视青年人胃癌的早期诊断，尽早行根治性手术，有助于改善患者预后。

关键词: 青年人, 胃癌, 临床病理, 生存分析