Abstract: 【Abstract】 Objective To observe the effects of dexmedetomidine on propofol consumption, postoperative pain and agitation in patients undergoing tympanoplasty. Methods Sixty ASA I or II patients scheduled for tympanoplasty were randomly allocated into two groups (n=30 each). Dex was administrated 1μg.kg-1 intravenously 10mins before induction and then continuously infused with a rate of 0.3μg.kg-1.h-1 in group D while normal saline was adopted instead of Dex in group C. In both groups, anesthesia was induced and maintained with propofol and remifentanil; target concentration of propofol was regulated to keep Narcotrend index (NI) within (46-20) range; BP, HR, propofol consumption, RS, RSS, VAS and fentanyl requirements were recorded. Results Propofol consumption during surgery and fentanyl requirements, RS, VAS score during anesthesia recovery were less in group D than group C while RSS score was higher in group D than group C(P<0.05). Conclusion Dexmedetomidine can effectively reduce propofol consumption and alleviate the incidence and degree of postoperative pain and agitation in patients undergoing tympanoplasty.

Key words: Dexmedetomidine, Tympanoplasty, Total intravenous anesthesia, Postoperative pain, Agitation

关键词: 【关键词】 右旋美托咪啶, 鼓室成形术, 全凭静脉麻醉, 术后疼痛, 躁动