Abstract: Objective To analyze Analysis of the effect of intraoperative application of nanocarbon-mixed injection in patients with differentiated thyroid cancer. Methods The clinical data of 92 cases of patients with total thyroidectomy + unilateral central zone lymphatic dissection admitted to Chengde City Central Hospital in Hebei Province from January 2021 to December 2023 were retrospectively collected and divided into the nanocarbon group （nanocarbon suspension injection treatment, n=46） and the control group （conventional surgical treatment, n=46） according to the different treatment methods. The treatment effects of the two groups were compared. Results The number of cervical lymph nodes cleared in the nanocarbon group （6.37±4.44） was more than that in the control group （t=3.919, P<0.001）. The rate of cervical lymph node metastasis （56.5%） was higher than that of the control group （χ²=10.172, P=0.001）, and the misdissection of parathyroid gland rate （6.5%） was lower than that of the control group （χ²=4.389, P=0.036）. The incidence of hypocalcemic symptoms in the nanocarbon group within 7 d postoperatively （8.7%） was lower than that in the control group （χ²=4.842, P=0.028）, and the incidence of total associatedcomplications in the postoperative period within 7 d （13.0%） was lower than that in the control group （χ²=5.974, P=0.015）. Conclusion The intraoperative application of nanocarbon-mixed injection in patients with differentiated thyroid cancer was able to improve the detection rate of cervical lymph node metastasis, increase the number of cervical lymph nodes cleared as well as reduce the rate of misdissection of the parathyroid glands, and also reduce the incidence of complications related to the patients in the postoperative period of 7 d. It also had a significant impact on the reduction of the incidence of hypocalcemic symptoms in the patients within seven days after surgery.

Key words: differentiated thyroid cancer, nanocarbon suspension injection, number of lymph node dissection, parathyroid glands, complications

摘要： 目的 分析分化型甲状腺癌患者手术中应用纳米碳混悬注射液的治疗效果。方法 回顾性收集2021年1月至2023年12月河北省承德市中心医院收治的92例行甲状腺全切+单侧中央区淋巴清扫术患者的临床资料,根据治疗方法不同分为纳米碳组（纳米碳混悬注射液治疗,n=46）和对照组（常规手术治疗,n=46）,比较两组治疗效果。结果 纳米碳组的颈部淋巴结清扫个数（6.37±4.44）多于对照组（t=3.919,P<0.001）,颈部淋巴结转移的检出率（56.5%）高于对照组（χ²=10.172,P=0.001）,甲状旁腺误切率（6.5%）低于对照组（χ²=4.389,P=0.036）。纳米碳组术后7 d内低钙症状发生率（8.7%）低于对照组（χ²=4.842,P=0.028）,且术后7 d内总的相关并发症发生率（13.0%）低于对照组（χ²=5.974,P=0.015）。结论 分化型甲状腺癌患者手术中应用纳米碳混悬注射液,能够提高颈部淋巴结转移的检出率,增加颈部淋巴结清扫个数以及降低甲状旁腺的误切率,还可以降低患者术后7 d内相关并发症的发生率,并对降低患者术后7 d内低钙症状的发生率有显著影响。

关键词: 分化型甲状腺癌, 纳米碳混悬注射液, 淋巴结清扫个数, 甲状旁腺, 并发症