Abstract: Objective To explore the prognostic value of metabolic syndrome （MS） and its components in outcome of patients with non-Triple Negative Breast Cancer（non-TNBC）. Methods The study included the newly diagnosed non-TNBC during Jan 1 2016 and Mar 30 2017. Clinical and pathological data were collected, and the patients were followed up for 3 years. The Kaplan-Meier analysis was used to explore the association between the MS and its components and the overall survival （OS）. The prognosis factors were analyzed by the multivariable Cox proportional hazards regression models. Results 194 patients were included with 12 in MS group and 168 in non-MS group. During the follow-up, there were 2 patients died in MS group, which OS rate was 81.8%. While in the non-MS group, 2 patients died and the OS rate was 98.8% （P<0.05）. After adjusting the menopausal status age, tumor stage and pathological factors, MS was the independently risk factor for poor OS （HR=62.788, 95%CI：1.342-2937.323, P<0.05）. The patients with two or more items of hypertension, hyperglycemia and dyslipidemia had higher death risk, compared with the patient with only one or none of them （HR=23.397, 95%CI：1.918-285.405, P<0.05）. Conclusion MS was associated with poor prognosis of non-Triple Negative Breast Cancer.

Key words: metabolic syndrome, non-triple negative breast cancer, prognosis

摘要： 目的 探讨代谢综合征（MS）及其组份对非三阴型乳腺癌（non-TNBC）预后的影响。方法 分析2016年1月1日至2017年3月30日本单位入院的新诊断的non-TNBC患者。收集临床及病理资料并进行为期3年随访。Kaplan-Meier法探讨MS及其组份与患者生存预后的关系。用多因素COX回归分析探索影响预后的因素。结果 总入选194名患者,MS者有12人,非MS为168人（14人部分数据存在缺失）。MS组有2人死亡,3年生存率为81.8%;非MS组2人死亡,3年生存率为98.8%（P<0.05）。合并MS的患者死亡风险增高（HR=62.788, 95%CI： 1.342~2937.323, P<0.05）。同时合并高血压、血糖异常和血脂异常中的2项及以上的患者死亡风险比只存在一项或无异常的患者高（HR=23.397, 95%CI：1.918~285.405,P<0.05）。结论 代谢综合征增加非三阴型乳腺癌患者死亡风险。

关键词: 代谢综合征, 非三阴型乳腺癌, 预后