The effect of collagen type Ⅰ in the progression of pancreatic cancer

doi:10.3969/j.issn.1009-976X.2023.03.012

Abstract

Abstract: Pancreatic cancer （PC）is a malignant tumor with high incidence and high mortality. Although the current treatment strategies have made great progress, metastasis, recurrence and drug resistance of pancreatic cancer are still the main reasons for poor prognosis of patients. Collagen type I （Col-I） is a major extracellular matrix protein and is abnormally expressed in a variety of solid tumors. Recent studies have shown that Col-I is highly expressed in PC, which is closely related to the growth, metastasis, invasion, drug resistance and treatment of PC, and is a new potential therapeutic target for PC. This review focuses on the effects of Col-I on the progression of PCand provides new ideas for the diagnosis and targeted therapy of PC.

Key words: collagen type I, pancreatic cancer, proliferation, migration, adhesion

摘要： 胰腺癌（PC）是高发病率、高死亡率的恶性肿瘤,尽管目前在胰腺癌的治疗策略中已取得了较大的进展,但胰腺癌的转移、复发及高耐药性仍是大部分患者预后不良的主要原因。Ⅰ型胶原蛋白（Col-I）是人体中主要的细胞外基质蛋白,在多种实体肿瘤中表达异常并参与肿瘤的形成。最近研究表明,Col-I在胰腺癌中高度表达与胰腺癌的生长、转移、侵袭、耐药以及治疗密切相关,是胰腺癌新的潜在治疗靶点。该文重点介绍了COl-I 对胰腺癌发生发展的影响,为胰腺癌的诊断和靶向治疗提供新的思路。

关键词: Ⅰ型胶原蛋白;, 胰腺癌, 增殖, 迁移, 粘附

CLC Number:

R817.1

KANG Yi-xing, SU Yan-ze, ZHANG Chao-chuang, LEI De-feng, LIN Zhi-heng, WANG Rong-rui, CHEN Xiao, LIU Ji-kui. The effect of collagen type Ⅰ in the progression of pancreatic cancer[J]. Lingnan Modern Clinics In Surgery, 2023, 23(03): 277-282.

康熠星, 苏延泽, 张超创, 雷德锋, 林志恒, 王荣悦, 陈霄, 刘吉奎. Collagen type I在胰腺癌发展中的作用[J]. 岭南现代临床外科, 2023, 23(03): 277-282.

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