Abstract: Objective A retrospective, single center observational research to study the correlation between gastric xanthoma and early gastric cancer after radical eradication of Helicobacter pylori, in order to determine the predictive value of gastric xanthoma in the diagnosis of early gastric cancer after radical eradication of Helicobacter pylori. Methods Patients who successfully eradicated Helicobacter pylori in our hospital from 2018 to 2021 and were followed up by gastroscopy were selected to collect relevant case data. The cases finally confirmed as early gastric cancer by gastroscopy and pathology were classified into the study group, and the rest into the control group. Statistical analysis was conducted to analyze the correlation between gastric xanthoma and early gastric cancer after radical eradication of Helicobacter pylori. Results The proportion of patients with gastric xanthoma in the study group was significantly higher than that in the control group （71.1% vs. 13.9%,P < 0.05）. Logistic regression analysis showed that atrophy, intestinal metaplasia and gastric xanthoma were independent predictors of early gastric cancer detection after Helicobacter pylori eradication. Atrophy matched control analysis also identified gastric xanthoma as an independent predictor. Conclusion Gastric xanthoma can be used as a predictor of early gastric cancer after Helicobacter pylori eradication.

Key words: gastric xanthoma, Helicobacter pylori, early gastric cancer

摘要： 目的 通过胃黄色瘤与根治幽门螺旋杆菌后早期胃癌相关性的回顾性、单中心观察性研究,最终确定胃黄色瘤对诊断根治幽门螺旋杆菌后早期胃癌发生的预测价值。方法 选择2018~2021年在我院成功根治幽门螺旋杆菌且进行胃镜随访的病人,收集相关病例资料。所有病例。根据胃镜下检查并经病理最终证实为早期胃癌,归为病例组,其余归为对照组,分析胃黄色瘤与根治幽门螺旋杆菌后早期胃癌的相关性。结果 病例组胃黄色瘤患者比例显著高于对照组（71.1% vs. 13.9%;P < 0.05）。logistic回归分析发现,萎缩、肠上皮化生和胃黄色瘤是幽门螺旋杆菌根治后早期胃癌检测的独立预测因素。萎缩匹配对照分析也确定胃黄色瘤为独立预测因子。结论 胃黄色瘤可作为幽门螺旋杆菌根治后早期胃癌的预测指标。

关键词: 胃黄色瘤, 幽门螺旋杆菌, 早期胃癌