Abstract: Objective To analyze of risk factors of wound infection after laparoscopic radical resection of renal carcinoma and the significance of preoperative NLR and PLR. Methods A total of 861 patients undergoing laparoscopic radical resection of renal carcinoma in our hospital from December 2013 to December 2021 were enrolled in this study, in which patients with wound infection were used as the study group, and patients without wound infection were used as the control group. Serum NLR and PLR between study group and control group were compared, and operation room risk factors of patients with wound infection after surgery were statistically analyzed. Results Risk factors included non-laminar flow operating room, operation time >; 3 h and intraoperative hypothermia （P<; 0.05）; the levels of NLR and PLR showed significantly difference in the two groups, serum NLR combined with PLR of the area under curve （AUC） was greater than the single index, which was 0.837, the best diagnostic sensitivity was 80.2%, and the specificity was 85.4%. Conclusion Non-laminar flow operating room, operation time >; 3 h and intraoperative hypothermiawere risk factors for wound infection. Preoperative serum NLR and PLR were closely correlated with wound infection, which can be used as an important biological indicators for the diagnosis of postoperative wound infection.

Key words: laparoscopic radical resection of renal carcinoma, wound infection, risk factors, NLR, PLR

摘要： 目的 探讨腹腔镜肾癌根治术后手术切口感染的手术室相关因素分析及术前血清中性粒细胞与淋巴细胞比值（NLR）及血小板与淋巴细胞比值（PLR）的意义。方法 选取2013年12月~2021年12月在中国科学院大学宁波华美医院泌尿外科861例行腹腔镜肾癌根治术患者为研究对象,手术后合并切口感染的患者作为研究组,手术后未并发切口感染的患者作为对照组。同时比较研究组和对照组患者血清NLR及PLR水平,统计分析手术后发生切口感染的患者的手术室相关因素。结果 非层流手术室、手术时间>3 h、术中低体温（P<0.05）是手术后切口感染的独立危险因素;研究组血清NLR及PLR水平高于对照组;血清NLR及PLR联合诊断切口感染敏感度及特异度较高。结论 非层流手术室、手术时间>3 h、术中低体温是腹腔镜肾癌根治术后切口感染发生的危险因素,感染组患者血清NLR及PLR水平,可作为诊断术后感染及评估病情的重要生物学指标。

关键词: 腹腔镜肾癌根治术, 手术切口感染, 危险因素, NLR, PLR