Abstract: Objective To explore the significance of serum matrix metalloproteinase 11 （MMP-11） and transforming growth factor-β （TGF-β1） levels in patients with thoracic aortic aneurysm. Methods Thirty patients with thoracic aortic aneurysm who were treated in the hospital between July 2020 and December 2020 were selected as the research subjects and included in study group, and another 30 healthy volunteers were selected as controls and enrolled as control group. The differences in the expression levels of serum MMP-11 and TGF-β1 at the initial examination were compared between the two groups, and the correlation between serum MMP-11 and serum TGF-β1 in patients with thoracic aortic aneurysm was analyzed by pearson correlation coefficient. The patients in the study group were divided into true aneurysm subgroup and aortic dissecting aneurysm subgroup, and the differences in serum MMP-11 and TGF-β1 were compared. Results The levels of serum MMP-11 and TGF-β1 in study group were significantly higher than those in control group （P<0.05）. The level of serum MMP-11 in patients with thoracic aortic aneurysm was positively correlated with the level of serum TGF-β1 （P<0.05）. Serum levels of MMP-11 and TGF-β1 were significantly higher in true aneurysm subgroup than those in aortic dissecting aneurysm subgroup （P<0.05）. Conclusion There was a close relationship between MMP-11 expression and TGF-β1 regulation in patients with thoracic aortic aneurysm. Understanding the expression of MMP and TGF may be helpful for clinical prevention and treatment of thoracic aortic aneurysm

Key words: matrix metalloproteinase 11, transforming growth factor-β, thoracic aortic aneurysm, correlation, true aneurysm, aortic dissecting aneurysm

摘要： 目的 探究血清基质金属蛋白酶11（MMP-11）、转化生长因子-β（TGF-β1）水平在胸主动脉瘤患者中的检测意义。方法 选取我院2020年7月~2020年12月收治的30例胸主动脉瘤患者为研究对象,将其纳入研究组;再以30例健康体检志愿者为对照,将其纳入对照组。对比两组受试者初检时血清MMP-11、TGF-β1表达水平差异,经Pearson相关系数分析胸主动脉瘤患者血清MMP-11与血清TGF-β1水平的相关性;根据病理类型,将研究组患者分为真性动脉瘤组和主动脉夹层动脉瘤组两个亚组,比较其血清MMP-11、TGF-β1水平的差异。结果 研究组血清MMP-11、TGF-β1水平明显高于对照组（P<0.05）;胸主动脉瘤患者血清MMP-11与血清TGF-β1水平呈正相关性（P<0.05）;真性动脉瘤组患者血清MMP-11、TGF-β1水平明显高于主动脉夹层动脉瘤组（P<0.05）。结论 胸主动脉瘤患者中血清MMP-11表达与TGF-β1调控关系密切,了解MMP-11、TGF-β1表达水平有利于临床防治胸主动脉瘤。

关键词: 基质金属蛋白酶11, 转化生长因子-β, 胸主动脉瘤, 相关性, 真性动脉瘤, 主动脉夹层动脉瘤