Abstract: Objective To investigate the clinicopathological features of splenic metastatic tumor in order to improve the understanding of the disease. Methods The clinical data and pathological features of 56 patients with splenic metastatic tumor in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2012 to December 2020 were analyzed retrospectively, and the related literatures were reviewed. The tumor of lymphatic hematopoietic system involving spleen was excluded. Results There were 139 cases of splenic tumors, accounting for 11.82% of the cases of splenic surgery in our hospital in the same period. There were 44 cases of splenic lymphohematopoietic system-related tumors and 95 cases of non-lymphohematopoietic tumors, including 56 cases of metastatic tumors. Metastatic tumors accounted for 4.76% of the cases of splenic surgery in our hospital in the same period, and 40.29% of splenic neoplastic lesions in our hospital in the same period. Among the 56 patients with splenic metastatic tumors, there were 26 males and 30 females. The age of onset was ranged from 30 to 76 years old, and the average age was 53 years old. Fifty-six cases of splenic metastatic tumors included pancreatic tumor （19 cases）, ovarian cancer （13 cases）, gastric tumor （9 cases）, liver cancer （6 cases）, intestinal adenocarcinoma （4 cases）, appendiceal mucinous adenocarcinoma （2 cases）, uterine choriocarcinoma （1 case）, breast invasive ductal carcinoma （1 case） and lung cancer （1 case）. The pathological morphology of metastatic tumor was similar to that of primary tumor, and immunohistochemical staining further confirmed the diagnosis. Conclusion The primary tumors of splenic metastases come from a wide range of sources, and the most common primary tumors are high-grade serous adenocarcinoma of the ovary and ductal adenocarcinoma of the pancreas. The combination of clinical, imaging and pathology is helpful to the correct diagnosis.

Key words: spleen, metastatic tumor, pathological diagnosis.

摘要： 目的 探讨脾转移性肿瘤的临床病理学特征。方法 回顾性分析2012年1月~2020年12月中山大学孙逸仙纪念医院的56例脾转移性肿瘤患者的临床资料及病理学特征,并复习相关文献。排除累及脾的淋巴造血系统肿瘤。结果 脾肿瘤139例,占同时期我院脾手术病例的11.82%。脾淋巴造血系统肿瘤44例,非淋巴造血系统肿瘤95例,其中转移性肿瘤56例。脾转移性肿瘤占同时期我院脾手术病例的4.76%,占同时期我院脾肿瘤性病变的40.29%。56例脾转移性肿瘤患者中,男性26例,女性30例。发病年龄30~76岁,平均年龄53岁。56例脾转移性肿瘤包括胰腺肿瘤（19例）、卵巢癌（13例）、胃肿瘤（9例）、肝癌（6例）、肠腺癌（4例）、阑尾粘液腺癌（2例）、子宫绒毛膜癌（1例）、乳腺浸润性导管癌（1例）、肺癌（1例）。脾转移性肿瘤病理学形态与原发肿瘤相似,免疫组化染色进一步明确诊断。结论 脾转移性肿瘤原发灶来源广泛,最常见的原发肿瘤是卵巢高级别浆液性腺癌和胰腺导管腺癌。通过临床-影像-病理三结合有助于正确诊断。

关键词: 脾, 转移性肿瘤, 病理诊断